| Name | TRPA1 |
|---|---|
| Synonyms | ANKTM 1; ANKTM1; Ankyrin like protein with transmembrane domains 1; Ankyrin like with transmembrane domains protein 1; TRPA 1; TRPA1; Transformation sensitive protein p120; Transient receptor potential cation channel subfamily A member 1… |
| Name | eugenol |
|---|---|
| CAS | 2-methoxy-4-(2-propen-1-yl)phenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20086034 | Earley S, Gonzales AL, Garcia ZI: A dietary agonist of transient receptor potential cation channel V3 elicits endothelium-dependent vasodilation. Mol Pharmacol. 2010 Apr;77(4):612-20. Epub 2010 Jan 19. Carvacrol causes concentration-dependent increases in the intracellular [Ca (2+)] of native cerebral artery endothelial cells and is more potent (EC (50) = 34 microM) than the TRPA1 agonist (EC (50) = 400 microM) or the TRPV3 agonist eugenol (EC (50) = 2.3 mM). |
33(0,1,1,3) | Details |
| 19135721 | Parnas M, Peters M, Dadon D, Lev S, Vertkin I, Slutsky I, Minke B: Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium. 2009 Mar;45(3):300-9. Epub 2009 Jan 9. In the present study we demonstrate by patch clamp whole cell recordings from Schneider 2 and Drosophila photoreceptor cells that carvacrol, a known activator of the thermoTRPs, TRPV3 and TRPA1 is an inhibitor of the Drosophila TRPL channels, which belongs to the TRPC subfamily. We also show that additional activators of TRPV3, eugenol, and are all inhibitors of the TRPL channel. |
1(0,0,0,1) | Details |
| 16617338 | Xu H, Delling M, Jun JC, Clapham DE: Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May;9(5):628-35. Epub 2006 Apr 16. Carvacrol, eugenol and are major components of plants such as oregano, savory, clove and thyme. In addition, carvacrol activates and rapidly desensitizes TRPA1, which may explain the pungency of oregano. |
1(0,0,0,1) | Details |