Protein Information

Name aryl hydrocarbon receptor
Synonyms AHR; Ah receptor; AhR; Aryl hydrocarbon receptor; Aryl hydrocarbon receptor precursor; Dioxin receptor; Ah receptors; AhRs…

Compound Information

Name eugenol
CAS 2-methoxy-4-(2-propen-1-yl)phenol

Reference List

PubMed Abstract RScore(About this table)
16972787 Kalmes M, Neumeyer A, Rio P, Hanenberg H, Fritsche E, Blomeke B: Impact of the arylhydrocarbon receptor on eugenol- and isoeugenol-induced cell cycle arrest in human immortalized keratinocytes (HaCaT). Biol Chem. 2006 Sep;387(9):1201-7.

In the present study we investigated whether the cell cycle arrest of eugenol and isoeugenol is mediated by the AhR in HaCaT cells.
166(2,2,2,6) Details
17275817 Han EH, Hwang YP, Jeong TC, Lee SS, Shin JG, Jeong HG: Eugenol inhibit 7,12-dimethylbenz [a] anthracene-induced genotoxicity in MCF-7 cells: Bifunctional effects on CYP1 and NAD (P) H:quinone oxidoreductase. FEBS Lett. 2007 Feb 20;581(4):749-56. Epub 2007 Jan 25.

Eugenol also suppressed the CYP1A induction by DMBA through decreased aryl hydrocarbon receptor activation and subsequent DNA binding.
81(1,1,1,1) Details