| Name | CD86 antigens |
|---|---|
| Synonyms | Activation B7 2 antigen; B lymphocyte activation antigen B7 2; B7 2; B70; BU63; CD28 antigen ligand 2; CD28LG2; CD86… |
| Name | eugenol |
|---|---|
| CAS | 2-methoxy-4-(2-propen-1-yl)phenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19338585 | An S, Kim S, Huh Y, Lee TR, Kim HK, Park KL, Eun HC: Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals. Contact Dermatitis. 2009 Apr;60(4):185-92. METHODS: We investigated the expression of CD54, CD86, CD83, CD80, and CD40 after a 1-day exposure to sensitizers (1-chloro-2,4-dinitrobenzene; 2,4-dinitrofluorobenzene; 5-chloro-2-methyl-4-isothiazolin-3-one; hexyl eugenol; hexahydrate; dichromate; 2-mercaptobenzothiazole; and ammonium tetrachloroplatinate) and non-sensitizers benzalkonium lactic acid, and |
8(0,0,1,3) | Details |
| 11033066 | Tuschl H, Kovac R, Weber E: The expression of surface markers on dendritic cells as indicators for the sensitizing potential of chemicals. Toxicol In Vitro. 2000 Dec;14(6):541-9. The sensitizers NiSO (4), dinitrochlorobenzene (DNCB), 2,4,6 trinitrobenzene (TNBS), alpha-hexylcinnamaldehyde (Cinn) and eugenol (Eu) induced the up-regulation of the co-stimulatory molecule CD86, of intercellular adhesion molecule CD54 and of the HLA-DR antigen. |
6(0,0,1,1) | Details |
| 17118622 | Miyazawa M, Ito Y, Yoshida Y, Sakaguchi H, Suzuki H: Phenotypic alterations and cytokine production in THP-1 cells in response to allergens. Toxicol In Vitro. 2007 Apr;21(3):428-37. Epub 2006 Oct 14. Indeed, all tested allergens, except eugenol (EU), caused significant increased changes in at least four of the analyzed six markers, while non-allergens did not induce any changes. We have previously shown that THP-1 cells, human acute monocytic leukemia cell line, can discriminate between allergens and irritants by measuring expression of surface markers, CD86 and CD54, following chemical exposure. |
4(0,0,0,4) | Details |
| 12423654 | Ashikaga T, Hoya M, Itagaki H, Katsumura Y, Aiba S: Evaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers. Toxicol In Vitro. 2002 Dec;16(6):711-6. Sensitizers such as dinitrochlorobenzene (DNCB), 2-mercaptobenzothiazole (MBT), eugenol, p-phenylenediamine (PPDA) and ammonium tetrachloroplatinate (Pt) enhanced CD86 expression on THP-1 cells, while and irritants such as methylsalicylate (MS), (SDS) and (DMSO) did not augment CD86 expression. |
3(0,0,0,3) | Details |
| 18547706 | Schreiner M, Peiser M, Briechle D, Stahlmann R, Zuberbier T, Wanner R: A new dendritic cell type suitable as sentinel of contact allergens. Toxicology. 2008 Jul 30;249(2-3):146-52. Epub 2008 May 4. DCrc showed a dose-dependent upregulation of CD86 after treatment with the contact allergens 2,4,6-trinitrobenzenesulfonic acid, the prohapten and alpha-hexyl |
2(0,0,0,2) | Details |
| 12029496 | De Smedt AC, Van Den Heuvel RL, Van Tendeloo VF, Berneman ZN, Schoeters GE, Weber E, Tuschl H: Phenotypic alterations and IL-1beta production in CD34 (+) progenitor- and monocyte-derived dendritic cells after exposure to allergens: a comparative analysis. Arch Dermatol Res. 2002 May;294(3):109-16. Epub 2002 Apr 9. The aim of this study was to determine the state of maturation/activation of both populations after exposure to several concentrations of four well-established model allergens eugenol, alpha-hexylcinnamaldehyde and 2,4,6-trinitrobenzene or the irritant We analyzed the surface expression of CD86, CD83 and HLA-DR and the production of IL-1beta. |
2(0,0,0,2) | Details |
| 11566557 | Tuschl H, Kovac R: Langerhans cells and immature dendritic cells as model systems for screening of skin sensitizers. Toxicol In Vitro. 2001 Aug-Oct;15(4-5):327-31. However, all skin sensitizers caused an up-regulation of the co-stimulatory molecule CD86, of intercellular adhesion molecule CD54 and of the HLA-DR antigen. The sensitizers NiSO (4), dinitrochlorobenzene, 2,4,6-trinitrobenzene alpha-hexylcinnamaldehyde and eugenol were applied. |
1(0,0,0,1) | Details |
| 11033063 | Guironnet G, Dalbiez-Gauthier C, Rousset F, Schmitt D, Peguet-Navarro J: In vitro human T cell sensitization to haptens by monocyte-derived dendritic cells. Toxicol In Vitro. 2000 Dec;14(6):517-22. The resulting cells exhibited the phenotype of mature DC, as assessed by the strong expression of HLA-DR, CD80, CD83 and CD86 antigens. The prohaptens eugenol and induced significant proliferation in one out of eight and in four out of 12 experiments, respectively. |
1(0,0,0,1) | Details |