Protein Information

Name olfactory receptor
Synonyms HSHT 2; Olfactory receptor; HSHT2; OR19 8; OR7E24P; OR7E24Q; Olfactory receptor OR19 14…

Compound Information

Name eugenol
CAS 2-methoxy-4-(2-propen-1-yl)phenol

Reference List

PubMed Abstract RScore(About this table)
12767924 Katada S, Nakagawa T, Kataoka H, Touhara K: Odorant response assays for a heterologously expressed olfactory receptor. . Biochem Biophys Res Commun. 2003 Jun 13;305(4):964-9.

3(0,0,0,3) Details
14991840 Josephson EM, Yilma S, Vodyanoy V, Morrison EE: Structure and function of long-lived olfactory organotypic cultures from postnatal mice. J Neurosci Res. 2004 Mar 1;75(5):642-53.

The first synapse in the olfactory pathway mediates a significant transfer of information given the restricted association of specific olfactory receptor neurons with specific glomeruli in the olfactory bulb.
We also recorded electro-olfactography responses to puffs of vapor collected over an odorant mixture containing ethyl butyrate, eugenol, (+) carvone, and (-) carvone from cultures as old as 21 DIV.
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15716417 Katada S, Hirokawa T, Oka Y, Suwa M, Touhara K: Structural basis for a broad but selective ligand spectrum of a mouse olfactory receptor: mapping the odorant-binding site. J Neurosci. 2005 Feb 16;25(7):1806-15.

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15341529 Katada S, Tanaka M, Touhara K: Structural determinants for membrane trafficking and G protein selectivity of a mouse olfactory receptor. J Neurochem. 2004 Sep;90(6):1453-63.

Each OR appears to recognize odorants based on similarities in molecular structures such that mOR-EG, a mouse OR, binds eugenol, vanillin, and some other structurally related odorants.
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9614232 Bozza TC, Kauer JS: Odorant response properties of convergent olfactory receptor neurons. . J Neurosci. 1998 Jun 15;18(12):4560-9.

DL-projecting ORNs showed responses to compounds with widely different structures, including carvone, eugenol, cinnamaldehyde, and acetophenone.
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15369603 Lu M, Staszewski L, Echeverri F, Xu H, Moyer BD: Endoplasmic reticulum degradation impedes olfactory G-protein coupled receptor functional expression. BMC Cell Biol. 2004 Sep 15;5:34.


Previously, we demonstrated that inefficient olfactory receptor (OR) expression at the plasma membrane is attributable, in part, to degradation of endoplasmic reticulum (ER)-retained ORs by the ubiquitin-proteasome system and sequestration of ORs in ER aggregates that are degraded by autophagy.
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14685265 Oka Y, Omura M, Kataoka H, Touhara K: Olfactory receptor antagonism between odorants. EMBO J. 2004 Jan 14;23(1):120-6. Epub 2003 Dec 18.

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19768509 Bengtsson JM, Wolde-Hawariat Y, Khbaish H, Negash M, Jembere B, Seyoum E, Hansson BS, Larsson MC, Hillbur Y: Field attractants for Pachnoda interrupta selected by means of GC-EAD and single sensillum screening. J Chem Ecol. 2009 Sep;35(9):1063-76. Epub 2009 Sep 11.

Synthetic sorghum and abutilon odor blends were attractive, but neither blend outperformed the previously tested attractants eugenol and methyl salicylate, of which the latter also was part of the abutilon blend.
The strong influence of single compounds led us to search for novel attractive compounds, and to investigate the role of individual olfactory receptor neurons (ORNs) in the perception of kairomones.
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15467253 Katada S, Touhara K: [A molecular basis for odorant recognition: olfactory receptor pharmacology]. Nippon Yakurigaku Zasshi. 2004 Oct;124(4):201-9.

Here we show that mOR-EG, a mouse olfactory receptor that was isolated from a eugenol-responsive cell, recognizes 22 different odorants with EC50 values ranging from a few microM to several hundred microM.
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11197816 Mizutani T, Sahara M, Kamakazu K, Hisamitsu T, Suzaki H: [Intracellular calcium kinetics after odorant stimulus in olfactory receptor cells isolated from mice]. Nippon Jibiinkoka Gakkai Kaiho. 2000 Dec;103(12):1292-9.

We found that intracellular Ca2+ concentrations rose after exposure to a set of odorants, including 3-ethoxy-4-hydroxy-benzaldehyde, caprylic acid, heptanoic acid, nonanoic acid, eugenol, phenethyl alcohol, and n-amyl acetate.
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15574817 Oka Y, Nakamura A, Watanabe H, Touhara K: An odorant derivative as an antagonist for an olfactory receptor. . Chem Senses. 2004 Nov;29(9):815-22.

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