Protein Information

Name intercellular adhesion molecule 1
Synonyms BB2; CD54; CD54 antigen; ICAM 1; ICAM1; Intercellular adhesion molecule 1; Intercellular adhesion molecule 1 precursor; Major group rhinovirus receptor…

Compound Information

Name eugenol
CAS 2-methoxy-4-(2-propen-1-yl)phenol

Reference List

PubMed Abstract RScore(About this table)
19101496 Bagis B, Atilla P, Cakar N, Hasanreisoglu U: An immunohistochemical evaluation of cell adhesion molecules in human dental pulp after tooth preparation and application of temporary luting cements. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Jan;107(1):137-44.

This reduction was significant only for ICAM-1 for 48-h eugenol-free samples.
44(0,1,3,4) Details
19338585 An S, Kim S, Huh Y, Lee TR, Kim HK, Park KL, Eun HC: Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals. Contact Dermatitis. 2009 Apr;60(4):185-92.

METHODS: We investigated the expression of CD54, CD86, CD83, CD80, and CD40 after a 1-day exposure to sensitizers (1-chloro-2,4-dinitrobenzene; 2,4-dinitrofluorobenzene; benzocaine; 5-chloro-2-methyl-4-isothiazolin-3-one; hexyl cinnamic aldehyde; eugenol; nickel sulfate hexahydrate; potassium dichromate; cobalt sulfate; 2-mercaptobenzothiazole; and ammonium tetrachloroplatinate) and non-sensitizers (sodium lauryl sulfate, benzalkonium chloride, lactic acid, salicylic acid, isopropanol, and dimethyl sulphoxide).
8(0,0,1,3) Details
11033066 Tuschl H, Kovac R, Weber E: The expression of surface markers on dendritic cells as indicators for the sensitizing potential of chemicals. Toxicol In Vitro. 2000 Dec;14(6):541-9.

The sensitizers NiSO (4), dinitrochlorobenzene (DNCB), 2,4,6 trinitrobenzene sulfonic acid (TNBS), alpha-hexylcinnamaldehyde (Cinn) and eugenol (Eu) induced the up-regulation of the co-stimulatory molecule CD86, of intercellular adhesion molecule CD54 and of the HLA-DR antigen.
6(0,0,1,1) Details
17118622 Miyazawa M, Ito Y, Yoshida Y, Sakaguchi H, Suzuki H: Phenotypic alterations and cytokine production in THP-1 cells in response to allergens. Toxicol In Vitro. 2007 Apr;21(3):428-37. Epub 2006 Oct 14.

Indeed, all tested allergens, except eugenol (EU), caused significant increased changes in at least four of the analyzed six markers, while non-allergens did not induce any changes.
We have previously shown that THP-1 cells, human acute monocytic leukemia cell line, can discriminate between allergens and irritants by measuring expression of surface markers, CD86 and CD54, following chemical exposure.
4(0,0,0,4) Details
11566557 Tuschl H, Kovac R: Langerhans cells and immature dendritic cells as model systems for screening of skin sensitizers. Toxicol In Vitro. 2001 Aug-Oct;15(4-5):327-31.

However, all skin sensitizers caused an up-regulation of the co-stimulatory molecule CD86, of intercellular adhesion molecule CD54 and of the HLA-DR antigen.
The sensitizers NiSO (4), dinitrochlorobenzene, 2,4,6-trinitrobenzene sulfonic acid, alpha-hexylcinnamaldehyde and eugenol were applied.
1(0,0,0,1) Details