| Name | glutathione S transferase |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | eugenol |
|---|---|
| CAS | 2-methoxy-4-(2-propen-1-yl)phenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7772744 | Aboobaker VS, Balgi AD, Bhattacharya RK: In vivo effect of dietary factors on the molecular action of role of non-nutrient phenolic compounds on the catalytic activity of liver fractions. In Vivo. 1994 Nov-Dec;8(6):1095-8. Certain phenolics notably (+/-) eugenol, vanillin and butylated hydroxyanisole were also found to induce cytosolic glutathione S-transferase activity that stimulated the formation of specific - conjugate. |
31(0,1,1,1) | Details |
| 10865886 | Vidhya N, Devaraj SN: Antioxidant effect of eugenol in rat intestine. . Indian J Exp Biol. 1999 Dec;37(12):1192-5. The activity of glutathione-S-transferases (GSTs) was increased significantly in both 15 day eugenol treated and 90-day eugenol treated groups. |
12(0,0,2,2) | Details |
| 8406240 | Rompelberg CJ, Verhagen H, van Bladeren PJ: Effects of the naturally occurring alkenylbenzenes eugenol and trans-anethole on drug-metabolizing enzymes in the rat liver. Food Chem Toxicol. 1993 Sep;31(9):637-45. Enhancement of cytosolic glutathione S-transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene was found for all eugenol- and trans-anethole-treated rats. |
6(0,0,1,1) | Details |
| 8645503 | Rompelberg CJ, Vogels JT, de Vogel N, Bruijntjes-Rozier GC, Stenhuis WH, Bogaards JJ, Verhagen H: Effect of short-term dietary administration of eugenol in humans. Hum Exp Toxicol. 1996 Feb;15(2):129-35. Glutathione-S-transferase (GST) activities were determined in erythrocytes and blood plasma. 3. |
1(0,0,0,1) | Details |
| 1402962 | Zheng GQ, Kenney PM, Lam LK: Sesquiterpenes from clove (Eugenia caryophyllata) as potential anticarcinogenic agents. J Nat Prod. 1992 Jul;55(7):999-1003. Bioassay-directed fractionation of clove terpenes from the plant Eugenia caryophyllata has led to the isolation of the following five active known compounds: beta-caryophyllene [1], beta-caryophyllene oxide [2], alpha-humulene [3], alpha-humulene epoxide I [4], and eugenol [5]. These compounds showed significant activity as inducers of the detoxifying enzyme glutathione S-transferase in the mouse liver and small intestine. |
1(0,0,0,1) | Details |
| 7786311 | Kumaravelu P, Dakshinamoorthy DP, Subramaniam S, Devaraj H, Devaraj NS: Effect of eugenol on drug-metabolizing enzymes of carbon tetrachloride-intoxicated rat liver. Biochem Pharmacol. 1995 May 26;49(11):1703-7. An overall decrease in drug-metabolizing enzymes, namely -cytochrome c reductase, -cytochrome reductase, hydroxylase, 7-ethoxy -O-deethylase, UDP-glucuronyltransferase and glutathione-S-transferase, was observed with CCl4 intoxication, with a subsequent decrease in cytochrome P450 and cytochrome b5 content. |
1(0,0,0,1) | Details |
| 10478835 | Singh A, Singh SP, Bamezai R: Modulatory potential of clocimum oil on mouse skin papillomagenesis and the xenobiotic detoxication system. Food Chem Toxicol. 1999 Jun;37(6):663-70. The present study was designed to elucidate the mechanistic inhibitory efficacy of clocimum (an eugenol rich variety of Ocimum gratissimum; Labiatae) oil on murine skin papillomagensis. Significant (P < 0.01) elevation in the hepatic levels of glutathione S-transferase (GST), sulfhydryl (-SH) and cytochrome b5 (Cyt. b5) was observed by the respective topical treatment of clocimum oil. |
1(0,0,0,1) | Details |
| 9436524 | Van Bladeren PJ: Influence of non-nutrient plant components on biotransformation enzymes. Biomed Pharmacother. 1997;51(8):324-7. Eugenol, for instance, lowers GST activity in man. Using the important class of the glutathione S-transferase (GST) as an example, the various phenotypic and genetic origins of interindividual variation are described. |
1(0,0,0,1) | Details |
| 16341694 | Young SC, Wang CJ, Hsu JD, Hsu JL, Chou FP: Increased sensitivity of Hep G2 cells toward the cytotoxicity of cisplatin by the treatment of piper betel leaf extract. Arch Toxicol. 2006 Jun;80(6):319-27. Epub 2005 Dec 9. These effects of PBL extract were compared to its major constitute, eugenol. |
0(0,0,0,0) | Details |
| 8620581 | Rompelberg CJ, Ploemen JH, Jespersen S, van der Greef J, Verhagen H, van Bladeren PJ: Inhibition of rat, mouse, and human glutathione S-transferase by eugenol and its oxidation products. Chem Biol Interact. 1996 Jan 5;99(1-3):85-97. The irreversible and reversible inhibition of glutathione S-transferases (GSTs) by eugenol was studied in rat, mouse and man. |
112(1,2,2,2) | Details |