Protein Information

Name caspase (protein family or complex)
Synonyms caspase; caspases

Compound Information

Name eugenol
CAS 2-methoxy-4-(2-propen-1-yl)phenol

Reference List

PubMed Abstract RScore(About this table)
17233906 Pisano M, Pagnan G, Loi M, Mura ME, Tilocca MG, Palmieri G, Fabbri D, Dettori MA, Delogu G, Ponzoni M, Rozzo C: Antiproliferative and pro-apoptotic activity of eugenol-related biphenyls on malignant melanoma cells. Mol Cancer. 2007 Jan 18;6:8.

Cytotoxic activity and apoptosis induced by treating melanoma cells with eugenol-related biphenyls was partially dependent by caspase activation.
31(0,1,1,1) Details
19389048 Fujimoto A, Sakanashi Y, Matsui H, Oyama T, Nishimura Y, Masuda T, Oyama Y: Cytometric analysis of cytotoxicity of polyphenols and related phenolics to rat thymocytes: potent cytotoxicity of resveratrol to normal cells. Basic Clin Pharmacol Toxicol. 2009 Jun;104(6):455-62. Epub 2009 Mar 11.

The compounds examined in this study were caffeic acid, rosmarinic acid, chlorogenic acid, (+)-catechin, 6-gingerol, sesamol, resveratrol, and eugenol.
In the presence of benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD-FMK), a pan-inhibitor of caspases, the resveratrol-induced increase in the population of cells with hypodiploidal DNA was partially inhibited.
1(0,0,0,1) Details
10871845 Chainy GB, Manna SK, Chaturvedi MM, Aggarwal BB: Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis. Oncogene. 2000 Jun 8;19(25):2943-50.

In addition, anethole abrogated TNF-induced apoptosis as measured by both caspase activation and cell viability.
The anethole analogues eugenol and isoeugenol also blocked TNF signaling.
1(0,0,0,1) Details