Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name eugenol
CAS 2-methoxy-4-(2-propen-1-yl)phenol

Reference List

PubMed Abstract RScore(About this table)
18814203 Kumar P, Singh VK, Singh DK: Kinetics of enzyme inhibition by active molluscicidal agents ferulic acid, umbelliferone, eugenol and limonene in the nervous tissue of snail Lymnaea acuminata. Phytother Res. 2009 Feb;23(2):172-7.

Ferulic acid, umbelliferone (Ferula asafoetida), eugenol (Syzygium aromaticum) and limonene (Carum carvi) are active molluscicidal components that inhibited the activity of alkaline phosphatase and acetylcholinesterase in in vivo and in vitro exposure of Lymnaea acuminata.
162(2,2,2,2) Details
1459632 Sen P, Maiti PC, Puri S, Ray A, Audulov NA, Valdman AV: Mechanism of anti-stress activity of Ocimum sanctum Linn, eugenol and Tinospora malabarica in experimental animals. Indian J Exp Biol. 1992 Jul;30(7):592-6.

RS also caused a generalized increase in enzyme activity and Os, eugenol or Tm effectively lowered the RS-induced elevations in lactate dehydrogenase (LDH) and alkaline phosphatase.
6(0,0,1,1) Details
15111634 Bonson S, Jeansonne BG, Lallier TE: Root-end filling materials alter fibroblast differentiation. J Dent Res. 2004 May;83(5):408-13.

Abbreviations: mineral trioxide aggregate (MTA), zinc-oxide eugenol cement (ZOEC), hybrid ionomer composite resin (HICR), reverse-transcriptase polymerase chain-reaction (RT-PCR).
MTA preferentially induced alkaline phosphatase expression and activity in both PDL and gingival fibroblasts.
2(0,0,0,2) Details
20036707 Yogalakshmi B, Viswanathan P, Anuradha CV: Investigation of antioxidant, anti-inflammatory and DNA-protective properties of eugenol in thioacetamide-induced liver injury in rats. Toxicology. 2010 Feb 9;268(3):204-12. Epub 2009 Dec 29.

Markers of liver injury (aspartate transaminase, alanine transaminase, alkaline phosphatase, gamma-glutamyl transferase and bilirubin), inflammation (myeloperoxidase, tumor necrosis factor-alpha and interleukin-6), oxidative stress (lipid peroxidation indices, protein carbonyl and antioxidant status) and cytochrome P4502E1 activity were assessed.
1(0,0,0,1) Details
15810969 Nakayama A, Ogiso B, Tanabe N, Takeichi O, Matsuzaka K, Inoue T: Behaviour of bone marrow osteoblast-like cells on mineral trioxide aggregate: morphology and expression of type I collagen and bone-related protein mRNAs. Int Endod J. 2005 Apr;38(4):203-10.


Furthermore, the calcium released from hydrated material, the cell proliferation ratio and alkaline phosphatase (ALP) activity were analysed, and the expression of type I collagen and bone-related protein mRNAs were evaluated.
1(0,0,0,1) Details
12814226 Thomson TS, Berry JE, Somerman MJ, Kirkwood KL: Cementoblasts maintain expression of osteocalcin in the presence of mineral trioxide aggregate. J Endod. 2003 Jun;29(6):407-12.


For gene expression on mineral trioxide aggregate and IRM, reverse transcriptase polymerase chain reaction was performed using primer sets for glyceraldehyde-3-phosphate dehydrogenase, type I collagen, alkaline phosphatase, osteocalcin, and bone sialoprotein after 3 and 5 days.
1(0,0,0,1) Details
16345082 Imazato S, Horikawa D, Ogata K, Kinomoto Y, Ebisu S: Responses of MC3T3-E1 cells to three dental resin-based restorative materials. J Biomed Mater Res A. 2006 Mar 15;76(4):765-72.

A zinc oxide eugenol cement [Super EBA (EBA)] was included in the study for comparison.
Cell attachment and proliferation were observed by scanning electron microscopy, and mitochondrial dehydrogenase and alkaline phosphatase (ALP) activities of the cells were evaluated.
1(0,0,0,1) Details
20104265 Suanarunsawat T, Devakul Na Ayutthaya W, Songsak T, Thirawarapan S, Poungshompoo S: Antioxidant Activity and Lipid-Lowering Effect of Essential Oils Extracted from Ocimum sanctum L. J Clin Biochem Nutr. 2010 Jan;46(1):52-9. Epub 2009 Dec 29.

The results showed that phenyl propanoid compounds including eugenol and methyl eugenol were the major constituents of EO.
EO suppressed the high serum lipid profile and atherogenic index as well as serum lactate dehydrogenase and creatine kinase MB subunit without significant effect on high serum levels of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase in rats fed with HC diet.
1(0,0,0,1) Details
16927871 el-Din AT: Molluscicidal effect of three monoterpenes oils on schistosomiasis and fascioliasis vector snails in Egypt. J Egypt Soc Parasitol. 2006 Aug;36(2):599-612.

The activities of acid phosphatase and alkaline phosphatase enzymes were found to be higher in the treated snails than in control ones.
Thymol, Linalool and Eugenol showed considerable molluscicidal effect against Biomphalaria alexandrina, Bulinus truncatus and Lymnneae natalensis.
1(0,0,0,1) Details
19716724 Min KS, Lee SI, Lee Y, Kim EC: Effect of radiopaque Portland cement on mineralization in human dental pulp cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Oct;108(4):e82-6. Epub 2009 Aug 28.


Alkaline phosphatase (ALP) activity was analyzed, and nodule formation was assessed by performing Alizarin Red S staining.
1(0,0,0,1) Details