| Name | IkappaBalpha |
|---|---|
| Synonyms | I kappa B alpha; Mad3; IKB alpha; IKBA; IKBalpha; IkappaBalpha; Inhibitor of kappa light chain gene enhancer in B cells alpha; MAD 3… |
| Name | eugenol |
|---|---|
| CAS | 2-methoxy-4-(2-propen-1-yl)phenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19851710 | Manikandan P, Vinothini G, Vidya Priyadarsini R, Prathiba D, Nagini S: Eugenol inhibits cell proliferation via NF-kappaB suppression in a rat model of gastric carcinogenesis induced by MNNG. Invest New Drugs. 2009 Oct 23. In the present study, we investigated the modulatory effects of eugenol on NF-kappaB signaling in a rat model of gastric carcinogenesis induced by N-methyl-N (')-nitro-N-nitrosoguanidine (MNNG) by analysing the expression of nuclear factor-kappaB (NF-kappaB) family members ((NF-kappaB (p50 and p65), inhibitor of kappaB alpha (IkappaBalpha), phosphorylated IkappaBalpha (p-IkappaBalpha), IkappaB kinase beta (IKKbeta)) and the NF-kappaB target genes that promote (e.g., cyclin D1, cyclin B and PCNA) or inhibit (e.g., p53, p21, and Gadd45) cell proliferation and cell survival. |
32(0,1,1,2) | Details |
| 10871845 | Chainy GB, Manna SK, Chaturvedi MM, Aggarwal BB: Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis. Oncogene. 2000 Jun 8;19(25):2943-50. In the present report we show that anethole is a potent inhibitor of TNF-induced NF-kappaB activation (an early response) as monitored by electrophoretic mobility shift assay, IkappaBalpha phosphorylation and degradation, and NF-kappaB reporter gene expression. The anethole analogues eugenol and also blocked TNF signaling. |
2(0,0,0,2) | Details |