Protein Information

Name dystrophin
Synonyms Apo dystrophin 1; BMD; CMD3B; DMD; DXS142; DXS164; DXS206; DXS230…

Compound Information

Name aldicarb
CAS

Reference List

PubMed Abstract RScore(About this table)
14499607 Grisoni K, Gieseler K, Mariol MC, Martin E, Carre-Pierrat M, Moulder G, Barstead R, Segalat L: The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin. J Mol Biol. 2003 Oct 3;332(5):1037-46.

We report here the molecular and functional characterization of the Caenorhabditis elegans gene stn-1 (F30A10.8), which encodes a syntrophin with homology to vertebrate alpha and beta-syntrophins. stn-1 is expressed in neurons and in muscles of C.elegans. stn-1 mutants resemble dystrophin (dys-1) and dystrobrevin (dyb-1) mutants: they are hyperactive, bend their heads when they move forward, tend to hypercontract, and are hypersensitive to the acetylcholinesterase inhibitor aldicarb.		 34(0,1,1,4) Details
9933302 Bessou C, Giugia JB, Franks CJ, Holden-Dye L, Segalat L: Mutations in the Caenorhabditis elegans dystrophin-like gene dys-1 lead to hyperactivity and suggest a link with cholinergic transmission. Neurogenetics. 1998 Dec;2(1):61-72.

Finally, the dys-1 mutants are hypersensitive to acetylcholine and to the acetylcholinesterase inhibitor aldicarb, suggesting that dys-1 mutations affect cholinergic transmission.		 5(0,0,0,5) Details