| 14979094 |
Costa C, Catania S, Silvari V: [Genotoxicity and activation of organophosphate and carbamate pesticides by cytochrome P450 2D6]. G Ital Med Lav Ergon. 2003 Jul-Sep;25 Suppl(3):81-2.
The role of the polymorphic cytochrome P450 (CYP) 2D6 isoform in catalysing the oxidative biotransformation of the organophosphate pesticide chlorpyriphos and the carbamate aldicarb into structures that inhibit cholinesterase and induce genotoxicity has been investigated in microsomal fraction, using quinine as a specific chemical inhibitor of CYP 2D6. |
32(0,1,1,2) |
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