Protein Information

Name cholinesterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name tetrachlorvinphos
CAS

Reference List

PubMed Abstract RScore(About this table)
14680990 Karanth S, Pope C: In vitro inhibition of blood cholinesterase activities from horse, cow, and rat by tetrachlorvinphos. Int J Toxicol. 2003 Nov-Dec;22(6):429-33.
33(0,1,1,3) Details
18166255 Karanth S, Holbrook T, MacAllister C, Pope CN: Selective inhibition of butyrylcholinesterase in vivo in horses by the feed-through larvacide Equitrol. Regul Toxicol Pharmacol. 2008 Mar;50(2):200-5. Epub 2007 Nov 28.

The organophosphate insecticide tetrachlorvinphos (TCVP, Rabon) is the active ingredient in "feed-through" larvacides (e.g., Equitrol) for fly control around horse stables.
5(0,0,0,5) Details
1364360 Ogawa Y, Suzuki S, Takada K, Sai K, Kamata E, Umemura T, Kaneko T, Kurokawa Y: [Twenty-eight-day repeated dose toxicity test for tetrachlorvinphos in Wistar rat]. Eisei Shikenjo Hokoku. 1990;(108):45-51.

The male and female rats showed dose-related inhibition of serum cholinesterase activity and erythrocyte acetylcholinesterase activity.
3(0,0,0,3) Details
72768 El-Sebae AH, Soliman SA, Elamayem MA, Ahmed NS: Neurotoxicity of organophosphorus insecticides Leptophos and EPN. J Environ Sci Health B. 1977;12(4):269-87.


The five tested organophosphorus insecticides were compared for their ability to inhibit cholinesterase, neurotoxic esterases and monoamine oxidase.
2(0,0,0,2) Details
17522960 Berger J, Valdez S, Puschner B, Leutenegger CM, Gardner IA, Madigan JE: Effects of oral tetrachlorvinphos fly control (Equitrol) administration in horses: physiological and behavioural findings. Vet Res Commun. 2008 Jan;32(1):75-92. Epub 2007 May 24.

TCVP exerts its effect by inhibiting the enzyme cholinesterase (ChE) leading to the accumulation of the neurotransmitter acetylcholine (AChE) in synapses of the central and peripheral nervous systems.
1(0,0,0,1) Details
8103733 Gromysz-Kalkowska K, Szubartowska E: Toxicity of tetrachlorvinphos to Rana temporaria L. Comp Biochem Physiol C. 1993 Jun;105(2):285-90.

The relatively high susceptibility of frogs to intoxication with tetrachlorwinfos is probably the result of a high affinity of cholinesterase to this pesticide, because of the presence of the P = O bond in its molecule.
1(0,0,0,1) Details