Protein Information

Name cholinesterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name coumaphos
CAS

Reference List

PubMed Abstract RScore(About this table)
11786345 Ivanov AN, Lukachova LV, Evtugyn GA, Karyakina EE, Kiseleva SG, Budnikov HC, Orlov AV, Karpacheva GP, Karyakin AA: Polyaniline-modified cholinesterase sensor for pesticide determination. Bioelectrochemistry. 2002 Jan;55(1-2):75-7.

The detection limits found (coumaphos, 0.002, trichlorfon, 0.04, aldicarb, 0.03, methiocarb, 0.08 mg l (-1)) make it possible to detect the pollutants in the waters on the level of limited threshold levels without sample preconcentration.
2(0,0,0,2) Details
4714334 Haufe WO: Interaction of pesticidal toxicity, parasites, and reversible anticholinesterase activity as stresses on growth rate in cattle infested with horn flies Haematobia irritans L. Toxicol Appl Pharmacol. 1973 May;25(1):130-44.

1(0,0,0,1) Details
984539 Gopal T, Oehme FW, Omer S: Influence of dietary protein on the effect of coumaphos and triflupromazine interaction in sheep. Am J Vet Res. 1976 Oct;37(10):1143-52.

One set of clinical signs, mortality rate, mean survival time, necropsy lesions, and plasma and erythrocyte cholinesterase (ChE) activity were monitored for each group.
1(0,0,0,1) Details
6380243 Gyrd-Hansen N, Kraul I: Obidoxime reactivation of organophosphate-inhibited cholinesterase activity in pigs. Acta Vet Scand. 1984;25(1):86-95.

1(0,0,0,1) Details
2339420 Silveira CL, Eldefrawi AT, Eldefrawi ME: Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases. Toxicol Appl Pharmacol. 1990 May;103(3):474-81.

There was poor correlation between the potencies of the OPs in reversibly inhibiting [3H] CD binding, and their anticholinesterase activities and toxicities.
Other OP insecticides had lower potencies, inhibiting less than 50% of 5 nM [3H] CD binding by 1 microM of EPN, coumaphos, dioxathion, dichlorvos, or chlorpyriphos.
1(0,0,0,1) Details
46730 Silvestri R, Himes JA, Edds GT: Repeated oral administration of coumaphos in sheep: interactions of coumaphos with bishydroxycoumarin, trichlorfon, and phenobarbital sodium. Am J Vet Res. 1975 Mar;36(3):289-92.

0(0,0,0,0) Details
565668 Obersteiner EJ, Sharma RP: Evaluation of cytotoxic responses caused by selected organophosphorus esters in chick sympathetic ganglia cultures. Can J Comp Med. 1978 Jan;42(1):80-8.


Concentrations that produced half-maximal effects ranged from 1 x 10 (-6) M (severely toxic) for methylparathian, diazinon, paraoxon, mevinphos, diisopropylfluorophosphate, tri-o-tolyl phosphate and its mixed isomers to a 1 x 10 (-3) M (intermediate) for malathion, leptophos, coumaphos, mono- and dicrotophos.
0(0,0,0,0) Details
3404542 Wright FC, Ahrens EH: Cholinesterase insensitivity: a mechanism of resistance in Mexican strains of Boophilus microplus (Acari: Ixodidae) against coumaphos. J Med Entomol. 1988 Jul;25(4):234-9.
81(1,1,1,1) Details
11676619 Tecles F, Ceron JJ: Determination of whole blood cholinesterase in different animal species using specific substrates. Res Vet Sci. 2001 Jun;70(3):233-8.

Butyryl- and propionylthiocholine were the substrates that yielded higher inhibitions after coumaphos exposure, whereas the use of acetylthiocholine showed the highest cholinesterase inhibition after imidocarb exposure.
42(0,1,2,7) Details
17474014 Pardio VT, Ibarra Nde J, Waliszewski KN, Lopez KM: Effect of coumaphos on cholinesterase activity, hematology, and biochemical blood parameters of bovines in tropical regions of Mexico. J Environ Sci Health B. 2007 May;42(4):359-66.

To assess the effect of coumaphos [O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl phosphorothioate] exposure on physiological responses during bovine production, acetylcolinesterase (AChE) and butyrylcholinesterase (BuChE) activities were measured in whole blood, erythrocytes, and plasma of healthy male steers (Bos Taurus x Bos indicus) sprayed with coumaphos at a non-lethal dose of 1 mg kg (- 1) body weight per day once every 14 (in vivo group) or 21 days (southern and central groups).
38(0,1,2,3) Details
10794385 Sheets LP: A consideration of age-dependent differences in susceptibility to organophosphorus and pyrethroid insecticides. Neurotoxicology. 2000 Feb-Apr;21(1-2):57-63.

The first involves multi-generation reproduction studies with rats that were treated with OP insecticides (coumaphos, fenamiphos, tribufos, trichlorfon, or oxydemeton-methyl) through the diet and examined for effects, including cholinesterase (ChE) inhibition.
31(0,1,1,1) Details
20134347 Thomas GA, Delaney LJ, Mueller C, Page E: Evaluation of coumaphos exposure among tick eradication workers. J Occup Environ Med. 2010 Feb;52(2):131-6.

OBJECTIVE: To evaluate both the cholinesterase monitoring program and newer field methods of determining coumaphos exposure among tick eradication workers.
14(0,0,2,4) Details
2708629 Wright FC, Ahrens EH: Effect of selection pressure on the cholinesterase of Boophilus microplus (Acari: Ixodidae) resistant to coumaphos. J Econ Entomol. 1989 Apr;82(2):524-9.
12(0,0,2,2) Details
15110288 Suprun EV, Budnikov HC, Evtugyn GA, Brainina KhZ: Bi-enzyme sensor based on thick-film carbon electrode modified with electropolymerized tyramine. Bioelectrochemistry. 2004 Jun;63(1-2):281-4.

The bi-enzyme sensor makes it possible to determine substituted phenols and aromatic amines in the micromolar range of their concentrations and anticholinesterase pesticides with detection limits of 0.1 (Coumaphos) and 0.03 micromol l (-1) (Chloropyrifos-methyl).
7(0,0,1,2) Details
8523496 Fang TC, Chen KW, Wu MH, Sung JM, Huang JJ: Coumaphos intoxications mimic food poisoning. J Toxicol Clin Toxicol. 1995;33(6):699-703.

This diagnosis was confirmed by serial changes in RBC cholinesterase and pseudocholinesterase activity, and by the presence of coumaphos in the contaminated food.
6(0,0,1,1) Details
11061961 Tecles F, Martinez Subiela S, Bernal LJ, Ceron JJ: Use of whole blood for spectrophotometric determination of cholinesterase activity in dogs. Vet J. 2000 Nov;160(3):242-9.

6(0,0,0,6) Details
1115426 Silvestri R, Himes JA, Edds GT: Repeated oral administration of coumaphos in sheep: effects on erythrocyte acetylcholinesterase and other constituents. Am J Vet Res. 1975 Mar;36(3):283-7.

Treatment of sheep with an intravenous injection of the organophosphorous compound trichlorfon, insufficient to produce a significant effect on erythrocyte cholinesterase activity, produced additive effects with those of coumaphos.
6(0,0,1,1) Details
18968123 Gogol EV, Evtugyn GA, Marty JL, Budnikov HC, Winter VG: Amperometric biosensors based on nafion coated screen-printed electrodes for the determination of cholinesterase inhibitors. Talanta. 2000 Nov 1;53(2):379-89.

The detection limits were found to be 3.5x10 (-7) M for trichlorfon and 1.5x10 (-7) M for coumaphos.
3(0,0,0,3) Details
11743808 Pardio VT, Ibarra N, Rodriguez MA, Waliszewski KN: Use of cholinesterase activity in monitoring organophosphate pesticide exposure of cattle produced in tropical areas. J Agric Food Chem. 2001 Dec;49(12):6057-62.

Results of multivariate analysis showed that the general responses between the control and experimental groups (in vivo, monitoring and case studies) treated with Coumaphos and Fenthion were statistically different, and the general responses of these experimental groups were statistically different over time as well.
3(0,0,0,3) Details
9875697 Astroff AB, Freshwater KJ, Eigenberg DA: Comparative organophosphate-induced effects observed in adult and neonatal Sprague-Dawley rats during the conduct of multigeneration toxicity studies. Reprod Toxicol. 1998 Nov-Dec;12(6):619-45.

Five organophosphates: tribufos, oxydemeton-methyl, fenamiphos, coumaphos, and trichlorfon were evaluated for their potential to produce reproductive and neonatal toxicity following continuous dietary exposure during multigenerational reproduction toxicity studies in the Sprague-Dawley rat.
Significant inhibition of parental cholinesterase activities (plasma, erythrocyte, and brain) was similarly observed in both generations with all test compounds, with at least the highest concentrations.
3(0,0,0,3) Details
7187141 Shmidl JA, Cox DD, Mozier JO: Toxicology studies conducted in laboratory animals and cattle with coumaphos flowable formulation. Vet Hum Toxicol. 1982 Apr;24(2):87-90.

The lowest whole blood cholinesterase mean value for cattle sprayed once with a 0.5% concentration was 80% of the pretreatment value at 14 days post-treatment.
3(0,0,0,3) Details
12942229 Ivanov A, Evtugyn G, Budnikov H, Ricci F, Moscone D, Palleschi G: Cholinesterase sensors based on screen-printed electrodes for detection of organophosphorus and carbamic pesticides. Anal Bioanal Chem. 2003 Oct;377(4):624-31. Epub 2003 Aug 26.

The biosensors developed make it possible to detect down to 2 x 10 (-8) mol L (-1) chloropyrifos-methyl, 5 x 10 (-8) mol L (-1) coumaphos, and 8 x 10 (-9) mol L (-1) carbofuran in aqueous solution and grape juice.
2(0,0,0,2) Details