Protein Information

Name hemoglobin (protein family or complex)
Synonyms Hemoglobin; Hemoglobins

Compound Information

Name dimethyl phthalate
CAS dimethyl 1,2-benzenedicarboxylate

Reference List

PubMed Abstract RScore(About this table)
4009021 Rodgers GP, Schechter AN, Noguchi CT: Cell heterogeneity in sickle cell disease: quantitation of the erythrocyte density profile. J Lab Clin Med. 1985 Jul;106(1):30-7.


An increasing body of experimental evidence demonstrates that intracellular hemoglobin concentration and composition is a primary determinant of pathophysiology in sickle cell disease.
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20077217 Kwack SJ, Kim KB, Kim HS, Lee BM: Comparative toxicological evaluation of phthalate diesters and metabolites in Sprague-Dawley male rats for risk assessment. J Toxicol Environ Health A. 2009;72(21-22):1446-54.

In order to comparatively assess the systemic toxicity and sperm parameters, nine phthalate diesters, including di (2-ethylhexyl) phthalate (DEHP), di (n-butyl) phthalate (DBP), di-n-octyl phthalate (DnOP), diethyl phthalate (DEP), butylbenzyl phthalate (BBP), dimethyl phthalate (DMP), di-isodecyl phthalate (DIDP), diundecyl phthalate (DUP), and di-isononyl phthalate (DINP), and five phthalate monoesters, including mono (2-ethylhexyl) phthalate (MEHP), monobutyl phthalate (MBuP), monobenzyl phthalate (MBeP), monoethyl phthalate (MEP), monomethyl phthalate (MMP), and phthalic acid (PA) were administered orally to Sprague-Dawley male rats at 250 (phthalate monoesters and PA) or 500 mg/kg body weight (bw)/d (phthalate diesters) for 4 wk.
Significant decreases in red blood cell (RBC) and hematocrit (Ht) levels were observed in DEHP-treated rats, whereas significant increases in mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and platelet (PLT) levels were found in the DEHP-treated group.
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