| Name | CYP17A1 |
|---|---|
| Synonyms | CPT 7; CPT7; CYP17; CYP17A1; CYPXVII; Cytochrome P450 17A1; Cytochrome p450 XVIIA1; P450 C17… |
| Name | dibutyl phthalate |
|---|---|
| CAS | dibutyl 1,2-benzenedicarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17379376 | Ryu JY, Lee BM, Kacew S, Kim HS: Identification of differentially expressed genes in the testis of Sprague-Dawley rats treated with di (n-butyl) Toxicology. 2007 May 5;234(1-2):103-12. Epub 2007 Feb 17. In addition, the expression patterns of the steroidogenesis-related genes such as scavenger receptor class B-1 (SR-B1), steroidogenic acute regulated protein (StAR), P450 side chain cleavage (P450scc), CYP17, and CYP19 were further analyzed by RT-PCR. |
2(0,0,0,2) | Details |
| 15141095 | Lehmann KP, Phillips S, Sar M, Foster PM, Gaido KW: Dose-dependent alterations in gene expression and synthesis in the fetal testes of male rats exposed to di (n-butyl) Toxicol Sci. 2004 Sep;81(1):60-8. Epub 2004 May 12. DBP exposure resulted in significant dose-dependent reductions in mRNA and protein concentration of scavenger receptor, steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage, 3beta-hydroxysteroid dehydrogenase, and cytochrome P450c17. |
1(0,0,0,1) | Details |
| 14617579 | Thompson CJ, Ross SM, Gaido KW: Di (n-butyl) impairs transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism. Endocrinology. 2004 Mar;145(3):1227-37. Epub 2003 Nov 14. Significant decreases in production and mRNA expression of scavenger receptor B1, P450 (SCC), steroidogenic acute regulatory protein, and cytochrome p450c17 were observed as early as gd 17. |
1(0,0,0,1) | Details |
| 16809437 | Lahousse SA, Wallace DG, Liu D, Gaido KW, Johnson KJ: Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) exposure suggests a common initial genetic response at fetal and prepubertal ages. Toxicol Sci. 2006 Oct;93(2):369-81. Epub 2006 Jun 29. Finally, comparison of the prepubertal MEHP microarray data to similar data from fetal dibutyl phthalate (DBP) exposure showed conservation in both the identities of testicular genes altered and the direction of expression changes. Interestingly, a unique, dose-dependent expression pattern was observed for the transcription factor Nr0b1, steroidogenic genes (Cyp17a1 and StAR), and a metabolism gene (Dhcr7). |
1(0,0,0,1) | Details |
| 15987825 | Thompson CJ, Ross SM, Hensley J, Liu K, Heinze SC, Young SS, Gaido KW: Differential steroidogenic gene expression in the fetal adrenal gland versus the testis and rapid and dynamic response of the fetal testis to di (n-butyl) Biol Reprod. 2005 Nov;73(5):908-17. Epub 2005 Jun 29. A DBP time-course experiment showed that testicular steroidogenesis was decreased within 1 h of DBP exposure and that this decrease preceded the repressed transcription of Star (steroidogenic acute regulatory protein); Scarb1 (scavenger receptor class B, member 1; also know as Sr-b1); Cyp11a1 (cytochrome P450, family 11, subfamily a, polypeptide 1; also known as P450SCC); and Cyp17a1 (cytochrome P450 family 17, subfamily a, polypeptide 1; also known as Cyp17). |
1(0,0,0,1) | Details |
| 17884934 | Kuhl AJ, Ross SM, Gaido KW: CCAAT/enhancer binding protein beta, but not steroidogenic factor-1, modulates the -induced dysregulation of rat fetal testicular steroidogenesis. Endocrinology. 2007 Dec;148(12):5851-64. Epub 2007 Sep 20. Prolonged in utero exposure of fetal male rats to dibutyl phthalate (DBP) can result in a feminized phenotype characterized by malformed epididymides, hypospadias, cryptorchidism, and retained thoracic nipples, among others. To understand these mechanisms in rats, in vivo DNase footprinting was adapted to provide a semiquantitative map of changes in DNA-protein interactions in the promoter region of steroidogenic genes, including steroidogenic acute regulatory, scavenger receptor B-1, cytochrome P450 side chain cleavage, and cytochrome P450 17A1, that are down-regulated after an in utero DBP exposure. |
1(0,0,0,1) | Details |
| 18621746 | Johnson KJ, McCahan SM, Si X, Campion L, Herrmann R, Barthold JS: The orl rat with inherited cryptorchidism has increased susceptibility to the testicular effects of in utero dibutyl phthalate exposure. Toxicol Sci. 2008 Oct;105(2):360-7. Epub 2008 Jul 10. |
0(0,0,0,0) | Details |