Protein Information

Name superoxide dismutase
Synonyms IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD…

Compound Information

Name dibutyl phthalate
CAS dibutyl 1,2-benzenedicarboxylate

Reference List

PubMed Abstract RScore(About this table)
11248139 O'Brien ML, Twaroski TP, Cunningham ML, Glauert HP, Spear BT: Effects of peroxisome proliferators on antioxidant enzymes and antioxidant vitamins in rats and hamsters. Toxicol Sci. 2001 Apr;60(2):271-8.

Accordingly, we measured the activities of DT-diaphorase and superoxide dismutase (SOD) and the hepatic content of ascorbic acid and alpha-tocopherol in male Sprague-Dawley rats and Syrian hamsters fed 2 doses of 3 known peroxisome proliferators (dibutyl phthalate [DBP], gemfibrozil, and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid (Wy-14,643) for 6, 34, or 90 days.
6(0,0,1,1) Details
19386278 Prasanth GK, Divya LM, Sadasivan C: Effects of mono and di (n-butyl) phthalate on superoxide dismutase. . Toxicology. 2009 Jul 28;262(1):38-42. Epub 2009 Apr 19.

2(0,0,0,2) Details
17214610 Farombi EO, Abarikwu SO, Adedara IA, Oyeyemi MO: Curcumin and kolaviron ameliorate di-n-butylphthalate-induced testicular damage in rats. Basic Clin Pharmacol Toxicol. 2007 Jan;100(1):43-8.


While only DBP treatment significantly increased the testicular malondialdehyde level and gamma-glutamyl transferase activity (gamma-GT), it markedly decreased glutathione level, the testicular catalase, glucose-6-phosphate dehydrogenase, superoxide dismutase, sperm gamma-GT activities and serum testosterone level compared to the control group.
1(0,0,0,1) Details
17497641 Lee E, Ahn MY, Kim HJ, Kim IY, Han SY, Kang TS, Hong JH, Park KL, Lee BM, Kim HS: Effect of di (n-butyl) phthalate on testicular oxidative damage and antioxidant enzymes in hyperthyroid rats. Environ Toxicol. 2007 Jun;22(3):245-55.


Superoxide dismutase and glutathione peroxidase activities were significantly higher in the testes of the DBP or T3 + DBP groups.
1(0,0,0,1) Details
16835115 Huang Q, Wang Q, Tan W, Song G, Lu G, Li F: Biochemical responses of two typical duckweeds exposed to dibutyl phthalate. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2006;41(8):1615-26.

With the increase of DBP concentration, content of chlorophyll and soluble protein decreased sharply, and activity of anti-oxidant enzyme systems including catalase (CAT), superoxide dismutase (SOD) and malondialdehyde (MDA) content increased significantly and decreased afterwards.
1(0,0,0,1) Details
2110512 Yamamoto S, Nakadate T, Aizu E, Kato R: Anti-tumor promoting action of phthalic acid mono-n-butyl ester cupric salt, a biomimetic superoxide dismutase. Carcinogenesis. 1990 May;11(5):749-54.

1(0,0,0,1) Details
16824579 Liao CS, Yen JH, Wang YS: Effects of endocrine disruptor di-n-butyl phthalate on the growth of Bok choy (Brassica rapa subsp. chinensis). Chemosphere. 2006 Dec;65(10):1715-22. Epub 2006 Jul 7.


Based on proteome level studies two protein spots increased and were identified as superoxide dismutase (SOD) and peroxidase 21 precursor.
1(0,0,0,1) Details
15148917 Wang Y, Song L, Chen J, He J, Liu R, Zhu Z, Wang X: [Effects of di-butyl phthalate on sperm motility and oxidative stress in rats]. Zhonghua Nan Ke Xue. 2004 Apr;10(4):253-6.


The sperm VCL, VSL, VAP, BCF, ALH, LIN, MAD and STR in the cauda epididymis were assessed by computer assisted sperm analysis (CASA), and the activities of superoxide dismutase (SOD) and the contents of malondialdehyde (MDA) in serum and testis homogenate were measured simultaneously.
1(0,0,0,1) Details