Protein Information

Name catalase
Synonyms CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases…

Compound Information

Name dibutyl phthalate
CAS dibutyl 1,2-benzenedicarboxylate

Reference List

PubMed Abstract RScore(About this table)
11936225 Kim SH, Kim SS, Kwon O, Sohn KH, Kwack SJ, Choi YW, Han SY, Lee MK, Park KL: Effects of dibutyl phthalate and monobutyl phthalate on cytotoxicity and differentiation in cultured rat embryonic limb bud cells; protection by antioxidants. J Toxicol Environ Health A. 2002 Mar;65(5-6):461-72.

The IC50 values of MBuP for cytotoxicity and cell differentiation were 307.24 microg/ml (1.38 mM) and 142.61 microg/ml (0.64 mM), respectively. in order to determine whether free radicals are related to induction of cytotoxicity and inhibition of differentiation by DBP in limb bud cells, DBP was coadministered with several antioxidants, including catalase and vitamin E acetate to limb bud cells.
2(0,0,0,2) Details
6134555 Kawashima Y, Hanioka N, Matsumura M, Kozuka H: Induction of microsomal stearoyl-CoA desaturation by the administration of various peroxisome proliferators. Biochim Biophys Acta. 1983 Jul 12;752(2):259-64.


Activity of microsomal stearoyl-CoA desaturation in rat liver was increased, ranging from 2.1 to 3.6 times, in association with an increase in the activity of peroxisomal beta-oxidation and catalase following the administration of clofibric acid, di-(2-ethylhexyl) phthalate, dibutylphthalate or di-(2-ethylhexyl) adipate.
1(0,0,0,1) Details
17497641 Lee E, Ahn MY, Kim HJ, Kim IY, Han SY, Kang TS, Hong JH, Park KL, Lee BM, Kim HS: Effect of di (n-butyl) phthalate on testicular oxidative damage and antioxidant enzymes in hyperthyroid rats. Environ Toxicol. 2007 Jun;22(3):245-55.


Catalase (CAT) activity was significantly higher in the DBP treatment group, but the T3 + DBP group showed slightly lower DBP-induced CAT activity.
1(0,0,0,1) Details
16835115 Huang Q, Wang Q, Tan W, Song G, Lu G, Li F: Biochemical responses of two typical duckweeds exposed to dibutyl phthalate. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2006;41(8):1615-26.

With the increase of DBP concentration, content of chlorophyll and soluble protein decreased sharply, and activity of anti-oxidant enzyme systems including catalase (CAT), superoxide dismutase (SOD) and malondialdehyde (MDA) content increased significantly and decreased afterwards.
1(0,0,0,1) Details
17214610 Farombi EO, Abarikwu SO, Adedara IA, Oyeyemi MO: Curcumin and kolaviron ameliorate di-n-butylphthalate-induced testicular damage in rats. Basic Clin Pharmacol Toxicol. 2007 Jan;100(1):43-8.


While only DBP treatment significantly increased the testicular malondialdehyde level and gamma-glutamyl transferase activity (gamma-GT), it markedly decreased glutathione level, the testicular catalase, glucose-6-phosphate dehydrogenase, superoxide dismutase, sperm gamma-GT activities and serum testosterone level compared to the control group.
1(0,0,0,1) Details