Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name dibutyl phthalate
CAS dibutyl 1,2-benzenedicarboxylate

Reference List

PubMed Abstract RScore(About this table)
12209194 Marsman D: NTP technical report on the toxicity studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F1 Mice. Toxic Rep Ser. 1995 Apr;30:1-G5.

Elevations in alkaline phosphatase activities and bile acid concentrations in male and female rats receiving 20,000 or 40,000 ppm as adults were indicative of cholestasis.
2(0,0,0,2) Details
2391408 Fukuoka M, Zhou Y, Tanaka A, Ikemoto I, Machida T: Mechanism of testicular atrophy induced by di-n-butyl phthalate in rats. J Appl Toxicol. 1990 Aug;10(4):285-93.


Increases in the levels of inositol and the activities of alkaline phosphatase and lactate dehydrogenase were also observed.
1(0,0,0,1) Details
15562782 Wang Y, Song L, Zhu Z, Chen J, He J, Liu R, Wang X: [Effect of dibutyl phthalate on the biochemical enzymes and lipid peroxidation in rat testes]. Zhonghua Nan Ke Xue. 2004 Oct;10(10):729-33.

After 4-week DBP exposure, while alkaline phosphatase (ALP) activities in the serum revealed an increasing tendency, sorbitol dehydrogenase (SDH) activities were inhibited significantly in both the serum and the testis homogenate at the dosage of 1000 mg/(kg x d) compared with the control group (P < 0.01).
1(0,0,0,1) Details