Protein Information

Name cathepsin B
Synonyms APP secretase; APPS; Amyloid precursor protein secretase; CPSB; CTSB; Cathepsin B; Cathepsin B precursor; Cathepsin B1…

Compound Information

Name dibutyl phthalate
CAS dibutyl 1,2-benzenedicarboxylate

Reference List

PubMed Abstract RScore(About this table)
19582493 Isnansetyo A, Kamei Y: Bioactive substances produced by marine isolates of Pseudomonas. . J Ind Microbiol Biotechnol. 2009 Oct;36(10):1239-48. Epub 2009 Jul 7.

Some of these bioactive compounds are antimicrobial agents, and dibutyl phthalate and di-(2-ethylhexyl) phthalate have been reported to be cathepsin B inhibitors.
31(0,1,1,1) Details
18289850 Hoang VL, Li Y, Kim SK: Cathepsin B inhibitory activities of phthalates isolated from a marine Pseudomonas strain. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2083-8. Epub 2008 Jan 30.

Both dibutyl phthalate and di-(2-ethylhexyl) phthalate showed dose-dependent cathepsin B inhibitions with IC (50) of 0.42 and 0.38 mM, respectively.
14(0,0,2,4) Details