Protein Information

Name cytochrome c
Synonyms CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs

Compound Information

Name dibutyl phthalate
CAS dibutyl 1,2-benzenedicarboxylate

Reference List

PubMed Abstract RScore(About this table)
7115078 Walseth F, Toftgard R, Nilsen OG: Phthalate esters I: Effects on cytochrome P-450 mediated metabolism in rat liver and lung, serum enzymatic activities and serum protein levels. Arch Toxicol. 1982 May;50(1):1-10.


DBP decreased the lung concentration of cytochrome b5 and NADPH-cytochrome-c-reductase activity by about 30%.
1(0,0,0,1) Details
7140696 Melnick RL, Schiller CM: Mitochondrial toxicity of phthalate esters. Environ Health Perspect. 1982 Nov;45:51-6.

The effects of mono- and dibutyl phthalate and mono- and di (2-ethylhexyl) phthalate on energy-dependent K+ uptake, respiration rates, and succinate cytochrome c reductase activities of isolated rat liver mitochondria were evaluated.
7(0,0,1,2) Details
3969678 Melnick RL, Schiller CM: Effect of phthalate esters on energy coupling and succinate oxidation in rat liver mitochondria. Toxicology. 1985 Jan;34(1):13-27.


DBP and MEHP stimulated succinate state 4 respiration, impaired K+-valinomycin induced swelling with succinate, ascorbate, or ATP as the energy sources, and inhibited succinate state 3 respiration and succinate cytochrome c reductase activity.
1(0,0,0,1) Details
3099543 Walseth F, Nilsen OG: Phthalate esters: effects of orally administered dibutylphthalate on cytochrome P-450 mediated metabolism in rat liver and lung. Acta Pharmacol Toxicol. 1986 Oct;59(4):263-9.


DBP significantly increased the liver microsomal concentration of cytochrome P-450 (48%) at the lowest dose and NADPH-cytochrome-c-reductase activity (28-29%), at the two lower doses.
1(0,0,0,1) Details