Protein Information

Name beta glucuronidase
Synonyms Beta glucuronidase; Beta G1; Beta glucuronidase precursor; GUSB; MPS 7; MPS7; Beta G1s; Beta glucuronidase precursors

Compound Information

Name dibutyl phthalate
CAS dibutyl 1,2-benzenedicarboxylate

Reference List

PubMed Abstract RScore(About this table)
9768498 Coldham NG, Dave M, Sauer MJ: Analysis of di-n-butylphthalate biotransformation in cattle by liquid chromatography/ion trap mass spectrometry/mass spectrometry. J Mass Spectrom. 1998 Sep;33(9):803-10.


MBP was metabolised to a beta-glucuronidase sensitive compound (M-H)- m/z 397 whose spectrum contained daughter ions (m/z 175 and 221) consistent with the parent glucuronide.
2(0,0,0,2) Details
2365410 Srivastava S, Singh GB, Srivastava SP, Seth PK: Testicular toxicity of di-n-butyl phthalate in adult rats: effect on marker enzymes of spermatogenesis. Indian J Exp Biol. 1990 Jan;28(1):67-70.


The activity of sorbitol dehydrogenase was found to be significantly decreased while that of lactate dehydrogenase, gamma-glutamyl transpeptidase, beta-glucuronidase, and glucose-6-phosphate dehydrogenase, significantly increased in the animals exposed to 500 and 1000 mg/kg of DBP.
1(0,0,0,1) Details
6132798 Foster PM, Cook MW, Thomas LV, Walters DG, Gangolli SD: Differences in urinary metabolic profile from di-n-butyl phthalate-treated rats and hamsters. Drug Metab Dispos. 1983 Jan-Feb;11(1):59-61.


However, intestinal esterase activities were comparable in the two species, whereas the activities of testicular beta-glucuronidase were significantly higher in rats compared to hamsters.
1(0,0,0,1) Details
2350234 Srivastava SP, Srivastava S, Saxena DK, Chandra SV, Seth PK: Testicular effects of di-n-butyl phthalate (DBP): biochemical and histopathological alterations. Arch Toxicol. 1990;64(2):148-52.


The activities of enzymes associated with premeiotic spermatogenic cells, Sertoli cells or interstitial cells, beta-glucuronidase, gamma-glutamyl transpeptidase and glucose-6-phosphate dehydrogenase were significantly increased.
1(0,0,0,1) Details