| Name | MAPK (protein family or complex) |
|---|---|
| Synonyms | MAPK; mitogen activated protein kinase; mitogen activated protein kinases |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15888667 | Ledirac N, Antherieu S, d'Uby AD, Caron JC, Rahmani R: Effects of organochlorine insecticides on MAP kinase pathways in human HaCaT keratinocytes: key role of reactive species. Toxicol Sci. 2005 Aug;86(2):444-52. Epub 2005 May 11. The aim of this study was to investigate the effects of four OCs (dieldrin, endosulfan, heptachlor, and lindane) on mitogen-activated protein kinase (MAPK) cascades and more specifically to identify the mechanism underlying OC-induced ERK1/2 activation. |
31(0,1,1,1) | Details |
| 17102581 | Corcelle E, Djerbi N, Mari M, Nebout M, Fiorini C, Fenichel P, Hofman P, Poujeol P, Mograbi B: Control of the autophagy maturation step by the MAPK ERK and p38: lessons from environmental carcinogens. Autophagy. 2007 Jan-Feb;3(1):57-9. Epub 2007 Jan 21. Our work published in Cancer Research revealed that the sustained activation of the MAPK ERK pathway by the carcinogen Lindane or the MEK1 (+) oncogene alters autophagy selectively at the maturation step resulting in the accumulation of large defective autolysosomes. |
2(0,0,0,2) | Details |
| 18481421 | Yu HG, Liang XM, Hu YF, Wang YN, Yang KD: [Action mechanism of p,p'-DDE and/or beta-BHC on JNK and MAPK signal transduction pathways in rat Sertoli cells]. Zhonghua Nan Ke Xue. 2008 Apr;14(4):311-6. |
2(0,0,0,2) | Details |
| 12439862 | Hatakeyama M, Zou E, Matsumura F: Comparison of the characteristic of estrogenic action patterns of beta-HCH and heregulin beta1 in MCF-7 human breast cancer cells. J Biochem Mol Toxicol. 2002;16(5):209-19. It appears, therefore, that the action of the latter relies more heavily on the PI3K route as compared to that of the former which has been shown to mainly act through p42/44 MAPK. |
1(0,0,0,1) | Details |
| 16818664 | Corcelle E, Nebout M, Bekri S, Gauthier N, Hofman P, Poujeol P, Fenichel P, Mograbi B: Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity. Cancer Res. 2006 Jul 1;66(13):6861-70. |
62(0,2,2,2) | Details |