| Name | ERalpha |
|---|---|
| Synonyms | ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA… |
| Name | dibutyl phthalate |
|---|---|
| CAS | dibutyl 1,2-benzenedicarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16326419 | Kang SC, Lee BM: DNA methylation of estrogen receptor alpha gene by phthalates. J Toxicol Environ Health A. 2005 Dec 10;68(23-24):1995-2003. The phthalates are ubiquitous industrial plasticizers and include agents such as di (2-ethylhexyl) (DEHP), dibutyl phthalate (DBP), and butyl benzyl (BBP), which are classified as endocrine disruptors because of their anti-androgenic or pro-estrogenic effects. |
4(0,0,0,4) | Details |
| 19453209 | Rider CV, Hartig PC, Cardon MC, Wilson VS: Comparison of chemical binding to recombinant fathead minnow and human estrogen receptors alpha in whole cell and cell-free binding assays. Environ Toxicol Chem. 2009 Oct;28(10):2175-81. Several of the chemicals (17beta- ethinylestradiol, alpha-zearalanol, fulvestrant, dibutyl phthalate, benzyl butyl and cadmium displayed higher affinity for fhERalpha than for hERalpha in the whole cell assay, while only dibutyl phthalate had a higher affinity for fhERalpha than for hERalpha in the cell-free assay. |
3(0,0,0,3) | Details |
| 7556011 | Jobling S, Reynolds T, White R, Parker MG, Sumpter JP: A variety of environmentally persistent chemicals, including some plasticizers, are weakly estrogenic. Environ Health Perspect. 1995 Jun;103(6):582-7. A random screen of 20 organic man-made chemicals present in liquid effluents revealed that half appeared able to interact with the estradiol receptor. |
2(0,0,0,2) | Details |
| 19463926 | Ghisari M, Bonefeld-Jorgensen EC: Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions. Toxicol Lett. 2009 Aug 25;189(1):67-77. Epub 2009 May 20. We investigated in vitro the thyroid hormone-like and estrogenic activities of a range of widely used plasticizers and phenols including benzyl butyl (BBP), dibutyl phthalate (DBP), dioctyl (DOP), diisodecyl diisononyl (DINP), di (2-ethylhexyl) (DEHP), bis (2-ethylhexyl) (DEHA), 4-tert-octylphenol (tOP), 4-chloro- (CMP), (2,4-DCP), 2-phenylphenol (2-PP) and resorcinol. |
2(0,0,0,2) | Details |
| 11750080 | Yamasaki K, Takeyoshi M, Yakabe Y, Sawaki M, Imatanaka N, Takatsuki M: Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals. Toxicology. 2002 Jan 15;170(1-2):21-30. We performed a reporter gene assay for ERalpha-mediated transcriptional activation and an immature rat uterotrophic assay of 23 chemicals, to study the relationship between these two assays and to examine the usefulness of the reporter gene assay. The chemicals analyzed in the study were as follows: benzophenone, bisphenol A, bisphenol B, bisphenol F, p-cumyl dibutyl phthalate, dicyclohexylphthalate, equilin, 17alpha- ethynyl hematoxylin, nonylphenol mixture, 4-n-nonylphenol, norethindrone, norgestrel, octachlorostyrene, 4-n-octylphenol, 4-tert-octylphenol, tributyltin- and zearalenone. |
2(0,0,0,2) | Details |
| 17651883 | van Meeuwen JA, Ter Burg W, Piersma AH, van den Berg M, Sanderson JT: Mixture effects of estrogenic compounds on proliferation and pS2 expression of MCF-7 human breast cancer cells. Food Chem Toxicol. 2007 Nov;45(11):2319-30. Epub 2007 Jun 15. To investigate such interactions, several PC and SC were tested individually, in mixtures and as combinations of mixtures with E (2) for effects on ERalpha receptor mediated cell proliferation and regulated pS2 expression level in MCF-7 (bus) cells. PCs (coumestrol, or SCs (4-nonylphenol, octylphenol, beta-hexachlorocyclohexane, bisphenol A, methoxychlor, dibutyl phthalate) were mixed (PCmix and SCmix) either in concentrations reflecting human serum concentrations or at equipotent concentrations for estrogenicity. |
2(0,0,0,2) | Details |
| 15458795 | Seidlova-Wuttke D, Jarry H, Wuttke W: Pure estrogenic effect of benzophenone-2 (BP2) but not of bisphenol A (BPA) and dibutylphtalate (DBP) in uterus, vagina and bone. Toxicology. 2004 Dec 1;205(1-2):103-12. Therefore, we studied their binding properties to recombinant ERalpha and ERbeta protein and their effects in the uterus, vagina and bone of ovariectomized rats. |
1(0,0,0,1) | Details |
| 16466534 | Mahood IK, McKinnell C, Walker M, Hallmark N, Scott H, Fisher JS, Rivas A, Hartung S, Ivell R, Mason JI, Sharpe RM: Cellular origins of testicular dysgenesis in rats exposed in utero to di (n-butyl) Int J Androl. 2006 Feb;29(1):148-54; discussion 181-5. Therefore, the aim of the present study was to fully characterize the ITLCs induced by in utero DBP exposure in d25 rats using a number of LC- (3beta-HSD, P450 side-chain cleavage enzyme, insulin-like factor 3, oestrogen receptor alpha) and Sertoli cell- (vimentin, Wilm's tumour-1) specific markers. |
1(0,0,0,1) | Details |
| 12408638 | Tollefsen KE, Meys JF, Frydenlund J, Stenersen J: Environmental estrogens interact with and modulate the properties of plasma sex steroid-binding proteins in juvenile Atlantic salmon (Salmo salar). Mar Environ Res. 2002 Sep-Dec;54(3-5):697-701. Some of these chemicals, which are known to interact with the estrogen receptor (ER), were found to bind competitively to the Atlantic salmon (Salmo salar) SBP and potentially disrupt the endocrine function of these proteins. |
1(0,0,0,1) | Details |
| 18923996 | Ryu JY, Lee E, Kim TH, Lee YJ, Lee J, Lee BM, Kwack SJ, Jung KK, Han SY, Kim SH, Kacew S, Kim HS: Time-response effects of testicular gene expression profiles in Sprague-Dawley male rats treated with di (n-butyl) J Toxicol Environ Health A. 2008;71(23):1542-9. The levels of androgen receptor (AR), estrogen receptor-alpha (ER-alpha), and retinoid X receptor-gamma (RXR-r) expression decreased significantly in a time- or dose-dependent manner. |
1(0,0,0,1) | Details |
| 15513902 | Kim HS, Kim TS, Shin JH, Moon HJ, Kang IH, Kim IY, Oh JY, Han SY: Neonatal exposure to di (n-butyl) (DBP) alters male reproductive-tract development. J Toxicol Environ Health A. 2004 Dec;67(23-24):2045-60. In addition, the expressions of androgen receptor (AR), estrogen receptors (ERs), and steroidogenic factor-1 (SF-1) were also examined in the testes. |
1(0,0,0,1) | Details |
| 15347996 | Hashimoto Y, Moriguchi Y, Oshima H, Nishikawa J, Nishihara T, Nakamura M: Estrogenic activity of chemicals for dental and similar use in vitro. J Mater Sci Mater Med. 2000 Aug;11(8):465-8. The estrogenic activities of chemicals for dental and similar use were tested by a reporter gene assay (yeast two-hybrid system) and an /estrogen receptor (ER-alpha) competition binding assay (fluorescence polarization system). Among the 10 chemicals [bisphenol-A (BPA), bis-2-hydroxypropyl methacrylate (Bis-GMA), triethylene glycol dimethacrylate (TEGDMA), methyl methacrylate and 2-hydroxyethyl methacrylate (HEMA), dibutyl phthalate (DBP), n-butyl benzyl (BBP), n-butyl phthalyl n-butyl (BPBG), di-2-ethylhexyl (DEHP), and di-2-ethylhexyl (DOA)], which were diluted with DMSO to concentrations ranging from 5 x 10 (-7) to 5 x 10 (-3) M, and 17beta- (E2) as a positive control, BPA and BBP showed estrogenic activity in these two assays, while the remaining eight chemicals did not at the concentrations tested. |
1(0,0,0,1) | Details |
| 11411516 | Kobayashi S, Sugaya T, Sakata N, Uebayasi M, Sameshima K, Tanaka A: Prediction of endocrine disruptors based on a new structure-activity relationship for sex and environmental hormones using chemical hardness concept. Chem Pharm Bull. 2001 Jun;49(6):680-8. For instance, 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is classified in group II, therefore, it would bind with the thyroid receptor more than the estrogen receptor (group I). It appears that dibutyl phthalate would not interact with estrogen receptor because it does not belong to group I. |
1(0,0,0,1) | Details |