Protein Information

Name c ebp beta
Synonyms AGP/EBP; LAP; Alpha 1 acid glycoprotein/enhancer binding protein; C/EBP beta; CCAAT/enhancer binding protein beta; CEBPB; CRP 2; CRP2…

Compound Information

Name dibutyl phthalate
CAS dibutyl 1,2-benzenedicarboxylate

Reference List

PubMed Abstract RScore(About this table)
17912698 Kuhl AJ, Ross SM, Gaido KW: Using a comparative in vivo DNase I footprinting technique to analyze changes in protein-DNA interactions following phthalate exposure. J Biochem Mol Toxicol. 2007;21(5):312-22.


In vivo footprinting identified three regions of altered DNase digestibility following DBP treatment, and EMSA identified the corresponding transcription factors as SF-1, c/ebp beta, and GATA4.
3(0,0,0,3) Details
17884934 Kuhl AJ, Ross SM, Gaido KW: CCAAT/enhancer binding protein beta, but not steroidogenic factor-1, modulates the phthalate-induced dysregulation of rat fetal testicular steroidogenesis. Endocrinology. 2007 Dec;148(12):5851-64. Epub 2007 Sep 20.

Prolonged in utero exposure of fetal male rats to dibutyl phthalate (DBP) can result in a feminized phenotype characterized by malformed epididymides, hypospadias, cryptorchidism, and retained thoracic nipples, among others.
Results demonstrated altered DNase protection at regions mapping to CCAAT/enhancer binding protein beta (c/ebp beta) and steroidogenic factor-1 (SF-1).
2(0,0,0,2) Details