| 14575675 |
Fujita K, Nagaoka M, Komatsu Y, Iwahashi H: Yeast pheromone signaling pathway as a bioassay to assess the effect of chemicals on mammalian peptide hormones. Ecotoxicol Environ Saf. 2003 Nov;56(3):358-66.
However, in a cells treated with certain chemicals used in pesticides, fungicides, and industrial products (i.e., TPN (CAS No. 1897-45-6), thiuram (CAS No. 137-26-8), captan (CAS No. 133-06-2), oxine-copper (CAS No. 10380-28-6), zineb (CAS No. 12122-67-7), and ziram (CAS No. 137-30-4)) the induction of shmoo formation was suppressed even when commercial alpha-factor was added.
The FUS1-lacZ gene, which is transcriptionally regulated by a pheromone, was transferred into yeast and the effects of TPN, captan, zineb, and ziram, under sublethal conditions, were investigated: beta-Galactosidase levels declined to levels similar to that of untreated control cells when in the absence of the alpha-factor. |
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