Protein Information

Name calmodulin
Synonyms CALM; CAM; CALM 1; CALM 2; CALM 3; CALM1; CALM2; CALM3…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
12405966 Chepkova AN, Doreulee N, Yanovsky Y, Mukhopadhyay D, Haas HL, Sergeeva OA: Long-lasting enhancement of corticostriatal neurotransmission by taurine. . Eur J Neurosci. 2002 Oct;16(8):1523-30.

The LLETAU was not prevented by N-methyl-d-aspartate (NMDA)- or by GABAA receptor-antagonists, but was sensitive to the GlyR-antagonist strychnine and blocked by the competitive taurine uptake inhibitor guanidinoethylsulphonate (GES, 1 mm).
LLETAU depended on protein kinase C activation as it was blocked by chelerythrine, but was unaffected by trifluoperazine, and thus independent of calmodulin.
1(0,0,0,1) Details
11498962 Wang DS, Xu TL, Li JS: Modulation of glycine-activated chloride currents by substance P in rat sacral dorsal commissural neurons. Sheng Li Xue Bao. 1999 Aug;51(4):361-70.

The modulatory effect of substance P (SP) on strychnine-sensitive glycine (Gly) response was examined in neurons acutely dissociated from the rat sacral dorsal commissural nucleus (SDCN) using nystatin perforated patch recording configuration under voltage-clamp conditions.
The facilitatory action of SP on IGly could also be abolished by pretreatment with chelerythrine or KN-62 in different neurons, a finding suggesting that protein kinase C (PKC) or Ca2+/calmodulin-dependent protein kinase II (CaMK II) possibly contributes to an intracellular pathway of SP in the augmentation of IGly.
1(0,0,0,1) Details
17196941 Yan L, Suneja SK, Potashner SJ: Protein kinases regulate glycine receptor binding in brain stem auditory nuclei after unilateral cochlear ablation. Brain Res. 2007 Mar 2;1135(1):102-6. Epub 2007 Jan 2.

We found previously that unilateral cochlear ablation (UCA) in young adult guinea pigs decreased [3H] strychnine binding activity in several brain stem auditory nuclei.
This study determined if the UCA-induced deficit could be regulated by protein kinase C (PKC), protein kinase A (PKA) or Ca2+/calmodulin-dependent protein kinase II (CaMKII).
1(0,0,0,1) Details
11283224 Akopian A, Witkovsky P: Intracellular calcium reduces light-induced excitatory post-synaptic responses in salamander retinal ganglion cells. J Physiol. 2001 Apr 1;532(Pt 1):43-53.


In the presence of strychnine and picrotoxin, ganglion cells responded to light onset and offset with transient inward currents at -70 mV.
0(0,0,0,0) Details
10082275 Ren J, Ye JH, Liu PL, Krnjevic K, McArdle JJ: Cocaine decreases the glycine-induced Cl- current of acutely dissociated rat hippocampal neurons. Eur J Pharmacol. 1999 Feb 12;367(1):125-30.


The cocaine suppression of I (GLY) was unaffected by 1 microM tetrodotoxin and 1 microM strychnine.
0(0,0,0,0) Details