Protein Information

Name G protein
Synonyms G gamma I; Guanine nucleotide binding protein 2; G protein; GNG 2; GNG2; GNGT 2; GNGT2; Guanine nucleotide binding protein gamma 2…

Compound Information

Name amitraz
CAS

Reference List

PubMed Abstract RScore(About this table)
7527851 Chen TH, Hsu WH: Inhibition of insulin release by a formamidine pesticide amitraz and its metabolites in a rat beta-cell line: an action mediated by alpha-2 adrenoceptors, a GTP-binding protein and a decrease in cyclic AMP. J Pharmacol Exp Ther. 1994 Dec;271(3):1240-5.

Thus, one mechanism by which amitraz and its metabolite BTS27271 decrease insulin release is by inhibiting adenylyl cyclase, an action mediated through a PTX-sensitive G-protein.
31(0,1,1,1) Details