| Name | 5 HT3 |
|---|---|
| Synonyms | 5 HT 3; 5 hydroxytryptamine 3 receptor; serotonin receptor; HTR 3; HTR3; 5 HT3; 5 HT3A; 5 HT3R… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12171579 | Johnston GA: Medicinal chemistry and molecular pharmacology of (C) receptors. . Curr Top Med Chem. 2002 Aug;2(8):903-13. (C) receptors belong to the nicotinicoid superfamily of ionotropic receptors that include nicotinic acetylcholine receptors, bicuculline-sensitive (A) receptors, strychnine-sensitive glycine receptors and 5HT3 serotonin receptors. |
31(0,1,1,1) | Details |
| 11380521 | Patten D, Foxon GR, Martin KF, Halliwell RF: An electrophysiological study of the effects of propofol on native neuronal ligand-gated ion channels. Clin Exp Pharmacol Physiol. 2001 May-Jun;28(5-6):451-8. To gain some insight into the effects of propofol at a range of native neuronal receptors, the present study has used an extracellular recording technique and determined its effects at (A), 5-HT3, P2X and nicotinic (nACh) receptors of the rat isolated vagus nerve and the (A) and strychnine-sensitive glycine receptor of the rat isolated optic nerve. |
31(0,1,1,1) | Details |
| 15566307 | Maksay G, Nemes P, Biro T: Synthesis of tropeines and allosteric modulation of ionotropic glycine receptors. J Physiol. 2002 Nov 1;544(Pt 3):727-39. These (nor) tropeines inhibited [(3) H] strychnine binding to glycine receptors in synaptosomal membranes of rat spinal cord. Displacing potencies were also measured for [(3) H] granisetron binding to 5-HT (3) type serotonin receptors of rat cerebral cortex. |
2(0,0,0,2) | Details |
| 12204190 | Jung ME, Lal H, Gatch MB: The discriminative stimulus effects of pentylenetetrazol as a model of anxiety: recent developments. table of contents. Several classes of compounds can modulate the PTZ discriminative stimulus including 5-HT (1A), 5-HT (3), and L-type calcium channel ligands. |
1(0,0,0,1) | Details |
| 12404628 | Breitinger HG, Becker CM: The inhibitory glycine receptor-simple views of a complicated channel. Chembiochem. 2002 Nov 4;3(11):1042-52. The strychnine-sensitive glycine receptor is the principal mediator of fast inhibitory synaptic transmission in the mammalian spinal cord and brain stem. As a member of the ligand-gated ion-channel family, it shares structural homology with the nicotinic (A/C) and serotonin 5-HT (3) receptors. |
1(0,0,0,1) | Details |
| 14561923 | Verbitsky M, Plazas PV, Elgoyhen AB: Functional expression and properties of a nicotinic alpha9/5-HT3A chimeric receptor. Neuroreport. 2003 Oct 27;14(15):1931-4. It was blocked by methyllycaconitine, strychnine, atropine and with the same rank order of potency as alpha9 receptors. |
1(0,0,0,1) | Details |
| 19726200 | Maksay G, Vincze Z, Nemes P: Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors. Bioorg Med Chem. 2009 Oct 1;17(19):6872-8. Epub 2009 Aug 20. Tropine esters displaced [(3) H] strychnine binding to glycine receptors of rat spinal cord with low Hill slopes. Affinities of three (nor) tropeines were different for glycine receptors but identical for 5-HT (3) receptors. |
1(0,0,0,1) | Details |
| 9895039 | Kostowski W, Bienkowski P: Discriminative stimulus effects of neuropharmacological characterization. Neurosci Biobehav Rev. 2002 Jun;26(4):429-39. The stimulus effect may be increased (i.e., stronger recognition) by N-cholinergic drugs dopaminergic drugs (apomorphine), and 5-HT3 receptor agonists (m-chlorophenylbiguanide). Further, some antagonists of strychnine-insensitive modulatory sites among the NMDA receptor complex (e.g., L-701,324) dose-dependently substitute for the discriminative stimulus. |
1(0,0,0,1) | Details |
| 12411519 | Bradaia A, Trouslard J: Fast synaptic transmission mediated by alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in lamina X neurones of neonatal rat spinal cord. Alcohol. 1999 Jan;17(1):63-80. The selective alpha7-containing nAChR (alpha7*nAChR) agonist (10 mM) induced a fast, rapidly desensitizing inward current, which was fully blocked by alpha-bungarotoxin (alpha-BgT; 50 nM) and strychnine (1 microM), two antagonists of alpha7*nAChRs. |
0(0,0,0,0) | Details |
| 11691868 | Neunlist M, Michel K, Reiche D, Dobreva G, Huber K, Schemann M: activates myenteric neurones in adult guinea-pigs. J Physiol. 2001 Nov 1;536(Pt 3):727-39. Strychnine (300 nM) reversibly abolished the -induced depolarisation and the Cl (-) channel blocker picrotoxin (100 microM) reduced the amplitude of the depolarisation by 55 +/- 5 %. |
0(0,0,0,0) | Details |
| 9886686 | Maksay G: Bidirectional allosteric modulation of strychnine-sensitive glycine receptors by tropeines and 5-HT3 serotonin receptor ligands. Neuropharmacology. 1998 Dec;37(12):1633-41. |
162(2,2,2,2) | Details |
| 16687139 | Jensen AA, Gharagozloo P, Birdsall NJ, Zlotos DP: Pharmacological characterisation of strychnine and brucine analogues at and alpha7 nicotinic acetylcholine receptors. Eur J Pharmacol. 2006 Jun 6;539(1-2):27-33. Epub 2006 May 9. Most strikingly, quaternization of strychnine and brucine with substituents possessing different steric and electronic properties completely eliminated the activity at the glycine receptors, whereas binding affinity to the alpha7/5-HT3 chimera was retained for the majority of the quaternary analogues. |
113(1,2,2,3) | Details |
| 12651653 | Koshizaki M, Kawamata M, Shimada SG, Saito Y, Collins JG: 5-HT3 receptors partially mediate halothane depression of spinal dorsal horn sensory neurons. Anesth Analg. 2003 Apr;96(4):1027-31 subtype 3 (5-HT (3)) receptors belong to the same ligand-activated ion-channel family as type A- and strychnine-sensitive glycine receptors, so we examined the possible involvement of receptor systems in halothane depression of spinal sensory neurons. |
33(0,1,1,3) | Details |
| 9351519 | Green MA, Halliwell RF: Selective antagonism of the (A) receptor by ciprofloxacin and biphenylacetic acid. Br J Pharmacol. 1997 Oct;122(3):584-90. Responses mediated by 5-HT3, nicotinic and P2X receptors in the vagus nerve and strychnine-sensitive glycine receptors in the optic nerve were little or unaffected by ciprofloxacin (100 microM), BPAA (100 microM) or the combination of these drugs (both at 100 microM). 6. |
32(0,1,1,2) | Details |
| 8894185 | Green KA, Lambert JJ, Cottrell GA: Ligand-gated ion channels opened by in molluscan neurones. Br J Pharmacol. 1996 Oct;119(3):602-8. 1. activated a fast (70 ms to half maximum) and desensitizing inward current through non-selective channels conducting predominantly monovalent cations in neurons of Helix aspersa. 2. alpha-Methyl- was equipotent with in activating this current, but the known selective agonists at vertebrate 5-HT3 receptors, 2-methyl- and arylbiguanides were ineffective (< 100 microM). which is inactive on vertebrate 5-HT3 receptors was a very weak agonist. 3. The responses were also antagonized by the non-specific antagonists (+)-tubocurarine and strychnine. 4. |
3(0,0,0,3) | Details |