Protein Information

Name MEST
Synonyms MEST; MEST protein; Mesoderm specific transcript; PEG 1; PEG1; PEG1/MEST; PEG1/MEST protein; Paternally expressed gene 1…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
11585691 Raza M, Shaheen F, Choudhary MI, Sombati S, Rafiq A, Suria A, Rahman A, DeLorenzo RJ: Anticonvulsant activities of ethanolic extract and aqueous fraction isolated from Delphinium denudatum. J Ethnopharmacol. 2001 Nov;78(1):73-8.

We carried out anticonvulsant screening of the ethanolic extract (EE) and aqueous fraction (AF) of this plant utilising the maximal electroshock (MEST) and subcutaneous pentylenetetrazole (scPTZ), bicuculline (scBIC), picrotoxin (scPTX) and strychnine (scSTN) tests for anticonvulsant activity.
7(0,0,1,2) Details
20303337 Kalinichev M, Starr KR, Teague S, Bradford AM, Porter RA, Herdon HJ: Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test. Brain Res. 2010 Mar 17.

Whether strychnine-sensitive or strychnine-insensitive glycine binding sites are involved in this effect remains to be determined.
3(0,0,0,3) Details
11507736 Raza M, Shaheen F, Choudhary MI, Suria A, Rahman AU, Sombati S, DeLorenzo RJ: Anticonvulsant activities of the FS-1 subfraction isolated from roots of Delphinium denudatum. Phytother Res. 2001 Aug;15(5):426-30.

The present study reports the anticonvulsant activities in the maximal electroshock test (MEST) and subcutaneous pentylenetetrazole (PTZ), bicuculline (BIC), picrotoxin (PIC)-induced seizures of the FS-1 subfraction (FS-1) that was obtained by purification of an aqueous fraction isolated from the roots of D. denudatum.
FS-1 had no effect on strychnine (STN)-induced extensor seizures.
2(0,0,0,2) Details