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Sandstrom P, Ginzel MD, Bearfield JC, Welch WH, Blomquist GJ, Tittiger C: Myrcene hydroxylases do not determine enantiomeric composition of pheromonal ipsdienol in Ips spp. J Chem Ecol. 2008 Dec;34(12):1584-92. Epub 2008 Nov 26.
Myrcene (7-methyl-3-methylene-1,6-octadiene) hydroxylation is likely one of the final reactions involved in the production of the Ips spp. (Coleoptera: Scolytidae) aggregation pheromone components, ipsdienol (2-methyl-6-methylene-2,7-octadien-4-ol) and ipsenol (2-methyl-6-methylene-7-octen-4-ol).
Microsomes, prepared from Sf9 cells co-expressing baculoviral-mediated recombinant IcCYP9T1 and house fly (Musca domestica) NADPH-cytochrome P450 reductase, converted myrcene to ~85%-(R)-(-)-ipsdienol. |
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