| Name | 11 beta HSD1 |
|---|---|
| Synonyms | 11 DH; 11 beta HSD1; 11 beta hydroxysteroid dehydrogenase 1; Corticosteroid 11 beta dehydrogenase isozyme 1; HDL; HSD11; HSD11B; HSD11B1… |
| Name | triadimefon |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18763812 | Kenneke JF, Mazur CS, Ritger SE, Sack TJ: Mechanistic investigation of the noncytochrome P450-mediated metabolism of triadimefon to triadimenol in hepatic microsomes. Chem Res Toxicol. 2008 Oct;21(10):1997-2004. Epub 2008 Sep 3. Using chemical inhibitors of P450s (i.e., and 1-aminobenzotriazole) and carbonyl reducing enzymes (i.e., glycyrrhetinic acid, quercitrin, and both triadimefon depletion and triadimenol formation were found to be mediated by 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1). |
81(1,1,1,1) | Details |
| 19541826 | Mazur CS, Kenneke JF, Goldsmith MR, Brown C: Contrasting influence of and a -regenerating system on the metabolism of carbonyl-containing compounds in hepatic microsomes. Drug Metab Dispos. 2009 Sep;37(9):1801-5. Epub 2009 Jun 18. In this study, we compared the effects of direct addition of and use of an NRS on the P450-mediated transformation of propiconazole and 11 beta-hydroxysteroid dehydrogenase type 1 (HSD1) carbonyl reduction of and the xenobiotic triadimefon in hepatic microsomes. In addition, we used in silico predictions as follows: 1) to show that 11 beta-HSD1 carbonyl reduction was energetically more favorable than oxidative P450 transformation; and 2) to calculate chemical binding score and the distance between the carbonyl group and the hydride to be transferred by to identify other 11 beta-HSD1 substrates for which reaction kinetics may be underestimated by direct addition of |
1(0,0,0,1) | Details |