| Name | cytosolic epoxide hydrolase |
|---|---|
| Synonyms | CEH; Epoxide hydratase; Cytosolic epoxide hydrolase; EPHX 2; EPHX2; Epoxide hydrolase 2; SEH; Soluble epoxide hydrolase… |
| Name | tridiphane |
|---|---|
| CAS | 2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)oxirane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3590187 | Moody DE, Hammock BD: The effect of tridiphane (2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl) oxirane) on hepatic epoxide-metabolizing enzymes: indications of peroxisome proliferation. Toxicol Appl Pharmacol. 1987 Jun 15;89(1):37-48. This study demonstrates that tridiphane does have in vivo effects on mammalian epoxide-metabolizing enzymes and extends the association of increased cytosolic epoxide hydrolase activity with peroxisome proliferation. |
81(1,1,1,1) | Details |
| 2043152 | Moody DE, Montgomery KA, Ashour MB, Hammock BD: Effects of environmentally encountered epoxides on mouse liver epoxide-metabolizing enzymes. Biochem Pharmacol. 1991 Jun 1;41(11):1625-37. Male mice were treated (i.p.) for 3 days with 15 different environmentally encountered epoxides, and the effects of these compounds on liver microsomal and cytosolic epoxide hydrolase (mEH and cEH), glutathione S-transferase (mGST and cGST) and carboxylesterase (mCE) activities were determined. The epoxides included the pesticides: heptachlor epoxide, dieldrin, tridiphane, and juvenoid R-20458; the natural products: disparlure, limonin, nomilin, and epoxymethyloleate; the endogenous steroids: epoxide, -alpha-epoxide, and epoxide; and the industrial or synthetic epoxides: epichlorohydrin, araldite, trans-stilbene oxide, and 4'-phenylchalcone oxide. |
1(0,0,0,1) | Details |