| Name | constitutive androstane receptor |
|---|---|
| Synonyms | CAR; CAR beta; CAR 1; CAR1; CARb; CARbeta; Constitutive activator of retinoid response; Constitutive active response… |
| Name | metofluthrin |
|---|---|
| CAS | [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-(1-propen-1-yl)cyclopropanecarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19378387 | Hirose Y, Nagahori H, Yamada T, Deguchi Y, Tomigahara Y, Nishioka K, Uwagawa S, Kawamura S, Isobe N, Lake BG, Okuno Y: Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes. Toxicology. 2009 Apr 5;258(1):64-9. High doses of Metofluthrin (MTF) have been shown to produce liver tumours in rats by a mode of action (MOA) involving activation of the constitutive androstane receptor leading to liver hypertrophy, induction of cytochrome P450 (CYP) forms and increased cell proliferation. |
81(1,1,1,1) | Details |
| 19176367 | Yamada T, Uwagawa S, Okuno Y, Cohen SM, Kaneko H: Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action. Toxicol Sci. 2009 Mar;108(1):59-68. Epub 2009 Jan 27. Furthermore, CYP2B induction by Metofluthrin was shown to involve activation of the constitutive androstane receptor in rat hepatocytes. |
81(1,1,1,1) | Details |