Protein Information

Name CYP2B
Synonyms CYP2B; CYP2B7; CYP2B7P; CYP2B protein; CYP2B7P1; CYP2B7P1 protein; CYP2B7P1 proteins

Compound Information

Name metofluthrin
CAS [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-(1-propen-1-yl)cyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
19176367 Yamada T, Uwagawa S, Okuno Y, Cohen SM, Kaneko H: Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action. Toxicol Sci. 2009 Mar;108(1):59-68. Epub 2009 Jan 27.

Furthermore, CYP2B induction by Metofluthrin was shown to involve activation of the constitutive androstane receptor in rat hepatocytes.
37(0,1,2,2) Details
19378387 Hirose Y, Nagahori H, Yamada T, Deguchi Y, Tomigahara Y, Nishioka K, Uwagawa S, Kawamura S, Isobe N, Lake BG, Okuno Y: Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes. Toxicology. 2009 Apr 5;258(1):64-9.
32(0,1,1,2) Details
19176366 Deguchi Y, Yamada T, Hirose Y, Nagahori H, Kushida M, Sumida K, Sukata T, Tomigahara Y, Nishioka K, Uwagawa S, Kawamura S, Okuno Y: Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation. Toxicol Sci. 2009 Mar;108(1):69-80. Epub 2009 Jan 27.
12(0,0,2,2) Details