Protein Information

Name c Src
Synonyms ASV; SRC1; Avian sarcoma virus protein; Proto oncogene tyrosine protein kinase SRC; SRC; Tyrosine kinase pp60c src; Tyrosine protein kinase SRC 1; c SRC…

Compound Information

Name hexachlorobenzene
CAS 1,2,3,4,5,6-hexachlorobenzene

Reference List

PubMed Abstract RScore(About this table)
18295415 Randi AS, Sanchez MS, Alvarez L, Cardozo J, Pontillo C, Kleiman de Pisarev DL: Hexachlorobenzene triggers AhR translocation to the nucleus, c-Src activation and EGFR transactivation in rat liver. Toxicol Lett. 2008 Mar 15;177(2):116-22. Epub 2008 Jan 12.
84(1,1,1,4) Details
19879930 Garcia MA, Pena D, Alvarez L, Cocca C, Pontillo C, Bergoc R, de Pisarev DK, Randi A: Hexachlorobenzene induces cell proliferation and IGF-I signaling pathway in an estrogen receptor alpha-dependent manner in MCF-7 breast cancer cell line. Toxicol Lett. 2010 Feb 1;192(2):195-205. Epub 2009 Oct 30.

In addition, HCB (0.005 microM) increased c-Src activation, Tyr537-ERalpha phosphorylation and ERalpha down-regulation.
1(0,0,0,1) Details