| Name | estrogen receptor 2 |
|---|---|
| Synonyms | ER beta; ERb; ERbeta; ESR beta; ESR 2; ESR2; ESRB; ESRbeta… |
| Name | endosulfan |
|---|---|
| CAS | 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19479021 | Alyea RA, Watson CS: Differential regulation of dopamine transporter function and location by low concentrations of environmental estrogens and 17beta- Environ Health Perspect. 2009 May;117(5):778-83. Epub 2009 Jan 5. OBJECTIVE: We examined low concentrations of XEs [dieldrin, endosulfan, o', p'-dichlorodiphenyl-ethylene (DDE), nonylphenol (NP), and bisphenol A (BPA)] for nongenomic actions via action of membrane estrogen receptors (ERs). METHODS: We measured activity of the dopamine transporter (DAT) by the efflux of 3H- in nontransfected nerve growth factor-differentiated PC12 rat pheochromocytoma cells expressing membrane DAT, ER-alpha, ER-beta, and G-protein-coupled receptor 30. |
2(0,0,0,2) | Details |
| 9860891 | Gaido K, Dohme L, Wang F, Chen I, Blankvoort B, Ramamoorthy K, Safe S: Comparative estrogenic activity of wine extracts and organochlorine pesticide residues in food. Environ Health Perspect. 1998 Dec;106 Suppl 6:1347-51. The reconstituted organochlorine mixture contained 1,1,1-trichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl) ethane, 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane, 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene, endosulfan-1, endosulfan-2, p,p'-methoxychlor, and toxaphene; the relative proportion of each chemical in the mixture resembled the composition reported in a recent U.S. The following battery of in vitro 17 (E2)-responsive bioassays were utilized in this study: competitive binding to mouse uterine estrogen receptor (ER); proliferation in T47D human breast cancer cells; luciferase (Luc) induction in human HepG2 cells transiently cotransfected with C3-Luc and the human ER, rat ER-alpha, or rat ER-beta; induction of chloramphenicol acetyltransferase (CAT) activity in MCF-7 human breast cancer cells transfected with E2-responsive cathepsin D-CAT or kinase B-CAT plasmids. |
1(0,0,0,1) | Details |
| 19590685 | Zhu Z, Edwards RJ, Boobis AR: Increased expression of histone proteins during -mediated cell proliferation. Environ Health Perspect. 2009 Jun;117(6):928-34. Epub 2009 Feb 7. RESULTS: The estrogenic compounds 17beta- bisphenol A, and endosulfan produced similar protein profile changes in MCF-7 cells (phenotype: ERalpha (+)/ERbeta (+)), but had no effect on MDA-MB-231 (ERalpha (-)/ERbeta (+)), MCF-10F (ERalpha (-)/ERbeta (+)), or MCF-10A (ERalpha (-)/ERbeta (-)) cells. |
0(0,0,0,0) | Details |
| 15081833 | Gale WL, Patino R, Maule AG: Interaction of xenobiotics with estrogen receptors alpha and beta and a putative plasma sex hormone-binding globulin from channel catfish (Ictalurus punctatus). Gen Comp Endocrinol. 2004 May 1;136(3):338-45. The alkylphenolic compounds (4-octylphenol and 4-nonylphenol) displayed some ability to displace 3H-E2 binding from ERalpha and beta at high concentrations, but dieldrin and atrazine had little binding activity for both ER subtypes and endosulfan for ERbeta. |
82(1,1,1,2) | Details |
| 15261991 | Grunfeld HT, Bonefeld-Jorgensen EC: Effect of in vitro estrogenic pesticides on human oestrogen receptor alpha and beta mRNA levels. Toxicol Lett. 2004 Aug 1;151(3):467-80. We tested the effect of these nine pesticides on the human ERalpha and ERbeta mRNA steady state levels in the mamma cancer fibroblast MCF-7BUS cells using on-line RT-PCR. Endosulfan and pirimicarb alone decreased the ERalpha mRNA level weakly. |
3(0,0,0,3) | Details |
| 16626760 | Lemaire G, Mnif W, Mauvais P, Balaguer P, Rahmani R: Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines. Life Sci. 2006 Aug 15;79(12):1160-9. Epub 2006 Mar 27. In this report, forty-nine pesticides were tested for ERalpha and beta activation or inhibition in stable reporter cell lines, HELN ERalpha and ERbeta. Antagonistic activities toward hERalpha and hERbeta were shown in three (carbaryl, pentachlorophenol and 2,4,5-trichlorophenoxyacetic acid) and seven (chlordecone, methoxychlor, carbaryl, endosulfan, endrin, dieldrin, aldrin) pesticides, respectively. |
3(0,0,0,3) | Details |
| 9118870 | Shelby MD, Newbold RR, Tully DB, Chae K, Davis VL: Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays. Environ Health Perspect. 1996 Dec;104(12):1296-300. The assays were 1) competitive binding with the mouse uterine estrogen receptor, 2) transcriptional activation in HeLa cells transfected with plasmids containing an estrogen receptor and a response element, and 3) the uterotropic assay in mice. The chemicals studied were 17 beta- diethylstilbestrol, tamoxifen, 4-hydroxytamoxifen, methoxychlor, the methoxychlor metabolite 2,2-bis (p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), endosulfan, nonylphenol, o,p'-DDT, and kepone. |
1(0,0,0,1) | Details |