Protein Information

Name thyroxine binding globulin
Synonyms SERPINA 7; SERPINA7; Serpin A7; T4 binding globulin; TBG; Thyroxine binding globulin; Thyroxine binding globulin of serum; Thyroxine binding globulin precursor…

Compound Information

Name hexachlorobenzene
CAS 1,2,3,4,5,6-hexachlorobenzene

Reference List

PubMed Abstract RScore(About this table)
19590699 Dallaire R, Muckle G, Dewailly E, Jacobson SW, Jacobson JL, Sandanger TM, Sandau CD, Ayotte P: Thyroid hormone levels of pregnant inuit women and their infants exposed to environmental contaminants. Environ Health Perspect. 2009 Jun;117(6):1014-20. Epub 2009 Jan 29.

METHODS: We measured thyroid hormone parameters [thyroid stimulating hormone (TSH), free thyroxine (fT (4)), total triiodothyronine (T (3)), thyroxine-binding globulin (TBG)] and concentrations of several contaminants [PCB-153, hydroxylated metabolites of PCBs (HO-PCBs), pentachlorophenol (PCP) and hexachlorobenzene (HCB)] in maternal plasma at delivery (n = 120), in umbilical cord plasma (n = 95), and in infant plasma at 7 months postpartum (n = 130).
31(0,1,1,1) Details
19750101 Dallaire R, Dewailly E, Pereg D, Dery S, Ayotte P: Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adults. Environ Health Perspect. 2009 Sep;117(9):1380-6. Epub 2009 May 12.

METHODS: We measured thyroid parameters [thyroid-stimulating-hormone (TSH), free thyroxine (fT (4)), total triiodothyronine (tT (3)), and thyroxine-binding globulin (TBG)] and concentrations of 41 contaminants, including PCBs and their metabolites, organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), perfluorooctanesulfonate (PFOS), and a measure of dioxin-like compounds, detected in plasma samples from Inuit adults (n = 623).
Moreover, we found negative associations between fT (4) levels and hexachlorobenzene concentrations.
1(0,0,0,1) Details