Protein Information

Name CD8
Synonyms CD8; p32; MAL; CD8A; CD8a antigen; CD8a molecule; LEU2 T lymphocyte antigen; Leu2…

Compound Information

Name hexachlorobenzene
CAS 1,2,3,4,5,6-hexachlorobenzene

Reference List

PubMed Abstract RScore(About this table)
10207981 Bruder MC, Spanhaak S, Bruijntjes JP, Michielsen CP, Vos JG, Kuper CF: Intestinal T lymphocytes of different rat strains in immunotoxicity. . Toxicol Pathol. 1999 Mar-Apr;27(2):171-9.

The explorative study with the 2 model immunomodulating compounds demonstrated that hexachlorobenzene increased the number of intraepithelial T lymphocytes with CD8+ phenotype at the cost of T cells with CD4+ phenotype in Lewis rats.
6(0,0,1,1) Details
14644672 Bilrha H, Roy R, Moreau B, Belles-Isles M, Dewailly E, Ayotte P: In vitro activation of cord blood mononuclear cells and cytokine production in a remote coastal population exposed to organochlorines and methyl mercury. Environ Health Perspect. 2003 Dec;111(16):1952-7.

Cord blood samples were collected for organochlorine and mercury analyses and also to isolate cord blood mononuclear cells (CBMCs) for the in vitro assessment of cytokine production and expression of surface markers after mitogenic stimulation (CD4 (+) CD45RO (+), CD8 (+) CD45RO (+), CD3 (+) CD25 (+), and CD8 (+) HLA-DR (+)).
Blood mercury and plasma concentrations of polychlorinated biphenyls (PCBs), 1,1-dichloro-2,2-bis (4-chlorophenyl) ethylene (p,p'-DDE), and hexachlorobenzene (HCB) were significantly higher in the subsistence fishing group than in the reference group (p < 0.001).
1(0,0,0,1) Details