| Name | cytochrome c |
|---|---|
| Synonyms | CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs |
| Name | hexachlorobenzene |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorobenzene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 525897 | Elissalde MH Jr, Clark DE: metabolism by hexachlorobenzene-induced hepatic microsomal enzymes. Am J Vet Res. 1979 Dec;40(12):1762-6. Significant increases in the mean hepatic weight, the concentrations of hepatic microsomal protein, cytochrome P-450, cytochrome b5, and cytochrome c reductase activity occurred in the aminals given a ration containing 250 mg of hexachlorobenzene/kg for 21 days, when compared with their nontreated controls. |
6(0,0,1,1) | Details |
| 7126264 | Holme JA, Dybing E: Induction of liver microsomal cytochrome P-450 and associated monooxygenases by octachlorostyrene in inbred strains of mice. Biochem Pharmacol. 1982 Aug 1;31(15):2523-9. Single intraperitoneal injections of octachlorostyrene (OCS) and hexachlorobenzene in genetically polycyclic aromatic hydrocarbon "responsive' C57/BL/6 (B6) mice led to a time- and dose-dependent increase in the levels of liver microsomal cytochromes P-450 and b5 as well as in the activities of cytochrome P-450 (cytochrome c) reductase, ethylmorphine (EM) N-demethylase, 4-nitroanisole (PNA) O-demethylase and acetanilide 4-hydroxylase (AcA hydroxylase). |
6(0,0,1,1) | Details |
| 19182106 | Chiappini F, Alvarez L, Lux-Lantos V, Randi AS, Kleiman de Pisarev DL: Hexachlorobenzene triggers apoptosis in rat thyroid follicular cells. Toxicol Sci. 2009 Apr;108(2):301-10. Epub 2009 Jan 30. This process is associated with dose-dependent increases in cytochrome c release from the mitochondria and procaspase-9 processing to its active product. |
1(0,0,0,1) | Details |
| 7466831 | Debets FM, Strik JJ, Olie K: Effects of pentachlorophenol on rat liver changes induced by hexachlorobenzene, with special reference to porphyria, and alterations in mixed function oxygenases. Toxicology. 1980;15(3):181-95. Microsomal cytochrome P-450, -cytochrome c reductase, ethoxyresorufin O-de-ethylase, aminopyrine N-demethylase, and glucuronyl transferase increased to a maximum in 2-4 weeks in HCB and HCB + PCP fed rats. |
1(0,0,0,1) | Details |
| 7395266 | Vizethum W, Burkhardt F, Goerz G: Enzymic and electrophoretic characterization of the hexachlorobenzene-induced cytochrome P-450 in the liver of rat. Xenobiotica. 1980 Feb;10(2):145-50. The catalytic activity of the enzyme towards various substrates (dealkylation of 7-ethoxycoumarin, hydroxylation of biphenyl and -dependent reduction of cytochrome c) corresponds to that obtained in animals treated with a mixture of phenobarbital and benzpyrene. 2. |
1(0,0,0,1) | Details |
| 317704 | Vizethum W, Goerz G: Induction of the hepatic microsomal and nuclear cytochrome P-450 system by hexachlorobenzene, pentachlorophenol and trichlorophenol. Chem Biol Interact. 1979 Dec;28(2-3):291-9. |
0(0,0,0,0) | Details |
| 6208712 | Torinuki W, Miura T, Tagami H: Activation of the alternative complement pathway by 405 nm light in serum from porphyric rat. Acta Derm Venereol. 1984;64(5):367-72. Sera from hexachlorobenzene-induced porphyric rats were examined for evidence of complement activation. By sephadex G-75 chromatography, the irradiated serum had potent chemotactic activity eluted near the cytochrome C marker. |
1(0,0,0,1) | Details |
| 3952775 | Rozman K, Gorski JR, Rozman P, Parkinson A: Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria. Toxicol Lett. 1986 Jan;30(1):71-8. At the end of the experiment (day 97), the concentration of liver microsomal cytochrome P-450 and cytochrome bs and the activity of ethoxyresorufin-O-deethylase, pentoxyresorufin-O-dealkylase, aminopyrine-N-demethylase and UDP-glucuronosyl transferase were significantly induced, whereas the activity of -cytochrome c reductase and benzo [a] pyrene hydroxylase was not. |
1(0,0,0,1) | Details |
| 6439214 | Carpenter HM, Williams DE, Henderson MC, Bender RC, Buhler DR: Hexachlorobenzene-induced porphyria in Japanese quail. Biochem Pharmacol. 1984 Dec 1;33(23):3875-81. |
0(0,0,0,0) | Details |