Protein Information

Name glucose 6 phosphate dehydrogenase
Synonyms 6 phosphogluconolactonase; GDH; G6PDH; Glucose 6 phosphate dehydrogenase; GDH/6PGL endoplasmic bifunctional protein; GDH/6PGL endoplasmic bifunctional protein precursor; Glucose 1 dehydrogenase; Glucose dehydrogenase…

Compound Information

Name hexachlorobenzene
CAS 1,2,3,4,5,6-hexachlorobenzene

Reference List

PubMed Abstract RScore(About this table)
10435853 Alvarez L, Randi A, Alvarez P, Kolliker Frers R, Kleiman de Pisarev DL: Effect of hexachlorobenzene on NADPH-generating lipogenic enzymes and L-glycerol-3-phosphate dehydrogenase in brown adipose tissue. J Endocrinol Invest. 1999 Jun;22(6):436-45.

The effect of the in vivo administration of hexachlorobenzene (HCB) (100 mg/100 g bw) for 30 days, on the activities of brown adipose tissue (BAT) lipogenic enzymes, i.e. malic enzyme (ME), and glucose-6-phosphate dehydrogenase (G6PD) and the mitochondrial non lipogenic enzyme, L-glycerol-3-phosphate dehydrogenase (LG3PD), was studied in male Wistar rats, submitted to various neurohormonal manipulations.
6(0,0,1,1) Details
7560808 Kleiman de Pisarev DL, Ferramola de Sancovich AM, Sancovich HA: Hepatic indices of thyroid status in rats treated with hexachlorobenzene. . J Endocrinol Invest. 1995 Apr;18(4):271-6.

The activities of the thyroid regulated mitochondrial enzyme L-glycerolphosphate dehydrogenase (LGPD) and cytosolic enzymes, malic enzyme (ME), glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) were assayed in livers of normal and HCB (100 mg/100 g bw) treated Wistar rats.
1(0,0,0,1) Details
731187 Mull RL, Winterlin WL, Peoples SA, Giri SN, Ocampo L: Hexachlorobenzene II. J Environ Pathol Toxicol. 1978 Jul-Aug;1(6):927-37.

0(0,0,0,0) Details
9777035 Loaiza Perez AI, Sancovich HA, Kleiman De Pisarev DL, Randi AS, Seisdedos M, Ferramola De Sancovich AM, Santisteban P: [Effect of thyroid hormones on the modulation of genetic expression of liver cytosolic malic enzyme, in rats poisoned with hexachlorobenzene]. Acta Physiol Pharmacol Ther Latinoam. 1998;48(3):125-36.

Previous findings from our laboratory have shown that HCB increased the activity of the liver thyroid-responsive enzymes: malic enzyme (ME), glucose-6-phosphate dehydrogenase (G6PD) without any change in the mytochondrial alpha-glycerophosphate dehydrogenase (alpha-GPD).
1(0,0,0,1) Details
9192204 Almeida MG, Fanini F, Davino SC, Aznar AE, Koch OR, Barros SB: Pro- and anti-oxidant parameters in rat liver after short-term exposure to hexachlorobenzene. Hum Exp Toxicol. 1997 May;16(5):257-61.

Concomitantly, liver antioxidant defenses are slightly modified, with decreased activity of glutathione peroxidase, superoxide dismutase and glucose-6-phosphate dehydrogenase contributing to an oxidative stress condition of the liver.
1(0,0,0,1) Details