| Name | transferase |
|---|---|
| Synonyms | 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80… |
| Name | hexachlorobenzene |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorobenzene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19182106 | Chiappini F, Alvarez L, Lux-Lantos V, Randi AS, Kleiman de Pisarev DL: Hexachlorobenzene triggers apoptosis in rat thyroid follicular cells. Toxicol Sci. 2009 Apr;108(2):301-10. Epub 2009 Jan 30. HCB (1, 10, 100 mg/kg body weight) induces apoptosis, evaluated by in situ end labeling of fragmented DNA, terminal deoxynucleotidyl transferase-mediated deoxy nick-end labeling, in rat thyroid glands. |
1(0,0,0,1) | Details |
| 7466831 | Debets FM, Strik JJ, Olie K: Effects of pentachlorophenol on rat liver changes induced by hexachlorobenzene, with special reference to porphyria, and alterations in mixed function oxygenases. Toxicology. 1980;15(3):181-95. Microsomal cytochrome P-450, -cytochrome c reductase, ethoxyresorufin O-de-ethylase, aminopyrine N-demethylase, and glucuronyl transferase increased to a maximum in 2-4 weeks in HCB and HCB + PCP fed rats. |
1(0,0,0,1) | Details |
| 12011480 | Wade MG, Parent S, Finnson KW, Foster W, Younglai E, McMahon A, Cyr DG, Hughes C: Thyroid toxicity due to subchronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium. Toxicol Sci. 2002 Jun;67(2):207-18. To investigate the potential effects of a complex, environmentally relevant mixture on the HPT axis, sexually mature male rats were administered a mixture of 16 common organochlorines (dichlorodiphenoxytrichloroethane [DDT], p,p'-dichlorodiphenoxydichloroethylene [p,p'-DDE], hexachlorobenzene [HCB], tetrachlorodibenzo-p-dioxin [TCDD], polychlorinated biphenyls [PCBs], methoxychlor, endosulfan, heptachlor, hexachlorocyclohexane, dieldrin, aldrin, mirex, and several chlorinated benzenes, and metal contaminants [lead, cadmium]). After 70 daily treatments by gavage, endpoints related to circulating thyroid hormone (serum [T (4)], [T (3)], thyroid stimulating hormone [TSH], and serum T (3) uptake [T (3)-up]), thyroid gland histomorphology (thyroid follicle cross sectional area, epithelial height, follicle roundness or aspect ratio, colloid/epithelial ratio) and hepatic metabolism of thyroid hormone (UDP-glucuronyl transferase [UGT] and outer-ring deiodinase [ORD]) were assessed. |
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| 15664263 | Alvarez L, Hernandez S, Martinez-de-Mena R, Kolliker-Frers R, Obregon MJ, Kleiman de Pisarev DL: The role of type I and type II 5' deiodinases on hexachlorobenzene-induced alteration of the hormonal thyroid status. Toxicology. 2005 Feb 28;207(3):349-62. HCB increased the activity of hepatic T4 diphosphoglucuronosyl transferase (UDPGT) in a time-dependent manner, without changes in T3 UDPGT. |
1(0,0,0,1) | Details |
| 3952775 | Rozman K, Gorski JR, Rozman P, Parkinson A: Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria. Toxicol Lett. 1986 Jan;30(1):71-8. At the end of the experiment (day 97), the concentration of liver microsomal cytochrome P-450 and cytochrome bs and the activity of ethoxyresorufin-O-deethylase, pentoxyresorufin-O-dealkylase, aminopyrine-N-demethylase and UDP-glucuronosyl transferase were significantly induced, whereas the activity of -cytochrome c reductase and benzo [a] pyrene hydroxylase was not. |
1(0,0,0,1) | Details |
| 12676599 | Ralph JL, Orgebin-Crist MC, Lareyre JJ, Nelson CC: Disruption of androgen regulation in the prostate by the environmental contaminant hexachlorobenzene. Environ Health Perspect. 2003 Apr;111(4):461-6. We also tested HCB for in vivo effects using transgenic mice in which the transgene was a prostate-specific, androgen-responsive promoter upstream of a chloramphenicol acetyl transferase (CAT) reporter gene. |
1(0,0,0,1) | Details |
| 1759844 | Goksoyr A, Husoy AM, Larsen HE, Klungsoyr J, Wilhelmsen S, Maage A, Brevik EM, Andersson T, Celander M, Pesonen M, et al.: Environmental contaminants and biochemical responses in flatfish from the Hvaler Archipelago in Norway. Arch Environ Contam Toxicol. 1991 Nov;21(4):486-96. The levels of several environmental contaminants, including selected polyaromatic hydrocarbons (PAH), organochlorines (DDT/DDE, hexachlorobenzene), 15 polychlorinated biphenyl (PCB) congeners, and polychlorinated dibenzofurans and dibenzo-p-dioxins, PCDF/PCDD), and heavy metals (Cd, Hg, Pb, and As) were analyzed in muscle and liver of three different flatfish species (dab, Limanda limanda; flounder, Platichthys flesus; plaice, Pleuronectes platessa) caught by gill netting at different sites in the Hvaler Archipelago. Indices of biochemical effects in liver S9-fractions were studied by measuring cytochrome P450-dependent monooxygenase and UDP-glucuronyl transferase activities, and by immunoquantitating cytochrome P450 1A1 using an indirect enzyme-linked immunosorbent assay (ELISA). |
1(0,0,0,1) | Details |
| 1539160 | D'Amour M, Charbonneau M: Sex-related difference in hepatic conjugation of hexachlorobenzene in the rat. Toxicol Appl Pharmacol. 1992 Feb;112(2):229-34. |
0(0,0,0,0) | Details |