Protein Information

Name CYP1A1
Synonyms AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1…

Compound Information

Name hexachlorobenzene
CAS 1,2,3,4,5,6-hexachlorobenzene

Reference List

PubMed Abstract RScore(About this table)
8018775 Guliaeva LF, Grishanova AIu, Liakhovich VV: [Induction of cytochromes P-4501A and 2B in various rat organs, subjected to hexachlorobenzene and aroclor 1254]. Biokhimiia. 1994 Apr;59(4):531-6.

The activity and content of CYP1A1, CYP1A2, CYP2B1 and CYP2B in the liver, lung and kidney of Wistar rats treated with hexachlorobenzene (HCB), Aroclor 1254 (AR), methylcholanthrene (MC) and phenobarbital (PB) were studied.
10(0,0,1,5) Details
17526421 Niimi S, Kim EY, Iwata H, Watanabe MX, Yasunaga G, Fujise Y, Tanabe S: Identification and hepatic expression profiles of cytochrome P450 1-4 isozymes in common minke whales (Balaenoptera acutorostrata). Comp Biochem Physiol B Biochem Mol Biol. 2007 Aug;147(4):667-81. Epub 2007 Apr 14.

To investigate whether or not these CYP expression levels are altered by contamination of organochlorine contaminants (OCs), mRNA levels of these CYPs in the liver of common minke whale were measured using a quantitative real-time RT-PCR method, and the quantified mRNA levels were employed for the statistical analysis with the residue levels of OCs including PCBs, DDTs (p,p'-DDT, p,p'-DDD and p,p'-DDE), chlordanes (cis-chlordane, trans-chlordane, cis-nonachlor, trans-nonachlor and oxychlordane), HCHs (alpha-, beta- and gamma-isomers) and hexachlorobenzene that have already been reported elsewhere.
Relationships among hepatic mRNA expression levels of these CYP2-4 isozymes together with CYP1A1 and CYP1A2 were also examined.
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6284402 Ivanovic V, Weinstein IB: Benzo [a] pyrene and other inducers of cytochrome P1-450 inhibit binding of epidermal growth factor to cell surface receptors. Carcinogenesis. 1982;3(5):505-10.

Progesterone, 17 beta-estradiol, benzo [e] pyrene, cholesterol, phenobarbital, 1,1-bis-(p-chlorophenyl)-2,2,2-trichloroethane, hexachlorobenzene or pregnenolone-16 alpha-carbonitrile, did not inhibit EGF binding.
2(0,0,0,2) Details
1759844 Goksoyr A, Husoy AM, Larsen HE, Klungsoyr J, Wilhelmsen S, Maage A, Brevik EM, Andersson T, Celander M, Pesonen M, et al.: Environmental contaminants and biochemical responses in flatfish from the Hvaler Archipelago in Norway. Arch Environ Contam Toxicol. 1991 Nov;21(4):486-96.

The levels of several environmental contaminants, including selected polyaromatic hydrocarbons (PAH), organochlorines (DDT/DDE, hexachlorobenzene), 15 polychlorinated biphenyl (PCB) congeners, and polychlorinated dibenzofurans and dibenzo-p-dioxins, PCDF/PCDD), and heavy metals (Cd, Hg, Pb, and As) were analyzed in muscle and liver of three different flatfish species (dab, Limanda limanda; flounder, Platichthys flesus; plaice, Pleuronectes platessa) caught by gill netting at different sites in the Hvaler Archipelago.
Indices of biochemical effects in liver S9-fractions were studied by measuring cytochrome P450-dependent monooxygenase and UDP-glucuronyl transferase activities, and by immunoquantitating cytochrome P450 1A1 using an indirect enzyme-linked immunosorbent assay (ELISA).
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3800966 Smith AG, Francis JE, Kay SJ, Greig JB, Stewart FP: Mechanistic studies of the inhibition of hepatic uroporphyrinogen decarboxylase in C57BL/10 mice by iron-hexachlorobenzene synergism. Biochem J. 1986 Sep 15;238(3):871-8.

Although, in further studies, total microsomal cytochrome P-450 content and ethoxyphenoxazone de-ethylase activity reached a peak a few days after dosing and had declined significantly at the time of maximum inhibition of the decarboxylase, additional treatment of HCB-dosed mice with a cytochrome P1-450 inducer, beta-naphthoflavone, enhanced the inhibition, whereas piperonyl butoxide, an inhibitor of cytochrome P-450, partially protected.
1(0,0,0,1) Details
3036697 Sweeney GD, Basford D, Krestynski F: The role of contaminants in hexachlorobenzene toxicity. IARC Sci Publ. 1986;(77):363-70.

To determine whether specific inducers of hepatic microsomal cytochrome P1-450, such as 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD), contributed to the difference in toxicity of these samples, induction of porphyria and activities of the cytochrome P1-450-dependent mono-oxygenase, ethoxyresorufin-O-deethylase (ERR), were compared in rats receiving HCB (0.2% w/w) or TCDD (10 micrograms/kg initial dose, then 2.5 micrograms/kg weekly).
1(0,0,0,1) Details
8330354 Smith AG, Carthew P, Francis JE, Cabral JR, Manson MM: Enhancement by iron of hepatic neoplasia in rats caused by hexachlorobenzene. Carcinogenesis. 1993 Jul;14(7):1381-7.

Studies of cytochrome P450 mediated activities showed that at 5 and 15 weeks HCB had induced EROD (an estimate of CYP1A1), PROD (CYP2B1 activity) and BROD activities (CYP2B1 but also other isoenzymes).
1(0,0,0,1) Details
2856071 Linko P, Yeowell HN, Gasiewicz TA, Goldstein JA: Induction of cytochrome P-450 isozymes by hexachlorobenzene in rats and aromatic hydrocarbon (Ah)-responsive mice. J Biochem Toxicol. 1986 Jun;1(2):95-107.

Western blots of liver microsomes from Ah-responsive C57BL/6J (B6) and nonresponsive DBA/2J (D2) mice demonstrated that HCB produced a large increase in P3-450 and a very small increase in P1-450 in the responsive strain.
1(0,0,0,1) Details
9918132 Akhtar RA, Smith AG: Chromosomal linkage analysis of porphyria in mice induced by hexachlorobenzene-iron synergism: a model of sporadic porphyria cutanea tarda. Pharmacogenetics. 1998 Dec;8(6):485-94.

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3879174 Merk H, von Zittwitz A, Bolsen K, Goerz G: Influence of (+)-propoxyphene on the hexachlorobenzene-induced porphyria of rats. Arzneimittelforschung. 1985;35(11):1685-7.

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7635426 Sinclair PR, Gorman N, Sinclair JF, Walton HS, Bement WJ, Lambrecht RW: Ascorbic acid inhibits chemically induced uroporphyria in ascorbate-requiring rats. Hepatology. 1995 Aug;22(2):565-72.


In ODS rats fed ascorbate at 90 but not 900 ppm in the diet, hexachlorobenzene caused hepatic URO accumulation, indicating that the effect of ascorbic acid is not unique to the regimen using methylcholanthrene.(ABSTRACT TRUNCATED AT 250 WORDS)
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3872633 Goerz G, Bolsen K, Merk H: Influence of chloroquine on the porphyrin metabolism. . Arch Dermatol Res. 1985;277(2):114-7.


Rats were treated with the well-known porphyrogen hexachlorobenzene (HCB) to induce experimental porphyria.
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