Protein Information

Name estrogen receptor
Synonyms ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA…

Compound Information

Name mirex
CAS

Reference List

PubMed Abstract RScore(About this table)
12215659 Porter KL, Chanda S, Wang HQ, Gaido KW, Smart RC, Robinette CL: 17beta-estradiol is a hormonal regulator of mirex tumor promotion sensitivity in mice. Toxicol Sci. 2002 Sep;69(1):42-8.

Consistent with a role for E2 and ERalpha and ERbeta, treatment of DMBA-initiated female mice with topical ICI 182,780, an estrogen-receptor antagonist, reduced mirex tumor multiplicity by 30%.
31(0,1,1,1) Details
12505301 Guillette LJ Jr, Vonier PM, McLachlan JA: Affinity of the alligator estrogen receptor for serum pesticide contaminants. Toxicology. 2002 Dec 27;181-182:151-4.

Two compounds, aldrin and Mirex showed little affinity for the aER.
2(0,0,0,2) Details
12167306 Okoumassoun LE, Averill-Bates D, Gagne F, Marion M, Denizeau F: Assessing the estrogenic potential of organochlorine pesticides in primary cultures of male rainbow trout (Oncorhynchus mykiss) hepatocytes using vitellogenin as a biomarker. Toxicology. 2002 Sep 16;178(3):193-207.

Non-toxic levels of these compounds competed with E (2) for binding to the estrogen receptor.
The aim of this study was to assess the estrogenic activity of the organochlorine pesticides o,p'-DDT, dieldrin, aldrin, heptachlor, mirex and DDT in rainbow trout hepatocyte cultures using vitellogenin (Vtg) as the biomarker.
1(0,0,0,1) Details