Protein Information

Name glucocorticoid receptor
Synonyms GCCR; GCR; GR; GRL; Glucocorticoid receptor; NR3C1; Glucocorticoid receptors

Compound Information

Name mirex
CAS

Reference List

PubMed Abstract RScore(About this table)
1673321 Thottassery JV, Yarbrough JD: Regulation of glucocorticoid receptors during adaptive liver growth. Am J Physiol. 1991 Apr;260(4 Pt 1):G603-9.

Because responsiveness to glucocorticoids is in part dependent on the number and affinity of glucocorticoid receptors (GR) we have measured hepatic GR levels and dexamethasone inducibility of tyrosine aminotransferase (TAT) in mirex-dosed INT, ADX, and THX rats.
32(0,1,1,2) Details
1638671 Sunahara GI, Chiesa A: Phorone (diisopropylidene acetone), a glutathione depletor, decreases rat glucocorticoid receptor binding in vivo. Carcinogenesis. 1992 Jul;13(7):1083-9.

Pretreatment with phorone or the carcinogens mirex and 3-methylcholanthrene significantly decreases GRc binding and nuclear uptake in vivo, as well as diminishes intracellular cytosolic GSH levels.
3(0,0,0,3) Details
2893471 Brown LD, Wilson DE, Yarbrough JD: Alterations in the hepatic glucocorticoid response to mirex treatment. Toxicol Appl Pharmacol. 1988 Feb;92(2):203-13.

The lack of hepatic TAT induction in the presence of increased plasma levels of corticosterone appears to be related to glucocorticoid receptor alterations in the liver of intact rats.
1(0,0,0,1) Details