Protein Information

Name Ha ras
Synonyms C H RAS; Transforming protein p21; N ras; HRAS1; HRASP; C H ras 1 protein N terminal fragment (37 AA); C has/bas p21 protein; C ras Ki 2 protein…

Compound Information

Name mirex
CAS

Reference List

PubMed Abstract RScore(About this table)
9328442 Kim TW, Porter KL, Foley JF, Maronpot RR, Smart RC: Evidence that mirex promotes a unique population of epidermal cells that cannot be distinguished by their mutant Ha-ras genotype. Mol Carcinog. 1997 Sep;20(1):115-24.

These results suggest that mirex may have highly specific effects on the proliferation of initiated cells and support the existence of a unique mirex mechanism and/or distinct population of mirex-promotable mutant Ha-ras epidermal cells.
44(0,1,3,4) Details
7554075 Kim TW, Smart RC: Lack of effect of retinoic acid and fluocinolone acetonide on mirex tumor promotion indicates a novel mirex mechanism. Carcinogenesis. 1995 Sep;16(9):2199-204.

Collectively, these results indicate that the promotional activity of mirex, as well as its weak proliferative response, result from a distinct promoter mechanism and/or that mirex promotes a unique population of epidermal cells that are insensitive to FA and RA and cannot be distinguished by their mutant Ha-ras genotype.
31(0,1,1,1) Details
8508502 Moser GJ, Robinette CL, Smart RC: Characterization of skin tumor promotion by mirex: structure-activity relationships, sexual dimorphism and presence of Ha-ras mutation. Carcinogenesis. 1993 Jun;14(6):1155-60.
18(0,0,3,3) Details
8293547 Meyer SA, Kim TW, Moser GJ, Monteiro-Riviere NA, Smart RC: Synergistic interaction between the non-phorbol ester-type promoter mirex and 12-O-tetradecanoylphorbol-13-acetate in mouse skin tumor promotion. Carcinogenesis. 1994 Jan;15(1):47-52.

0(0,0,0,0) Details