Protein Information

Name glutathione S transferases
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name monocrotophos
CAS

Reference List

PubMed Abstract RScore(About this table)
2267665 Siddiqui MK, Mahboob M, Mustafa M: Hepatic and extra hepatic glutathione depletion and glutathione-S-transferase inhibition by monocrotophos and its two thiol analogues. Toxicology. 1990 Dec 3;64(3):271-9.
112(1,2,2,2) Details
11746198 Mahboob M, Siddiqui MK: Alterations in hepatic detoxifying enzymes induced by new organophosphorus insecticides following subchronic exposure in rats. J Appl Toxicol. 2001 Nov-Dec;21(6):501-5.


The activity of hepatic glutathione S-transferase (GST) and UDP-glucuronyl transferase (UDPGT) and the level of glutathione (GSH) were estimated at 0, 45 and 90 days of treatment as well as 28 days after cessation of treatment.
1(0,0,0,1) Details
16872049 Singh M, Sandhir R, Kiran R: Erythrocyte antioxidant enzymes in toxicological evaluation of commonly used organophosphate pesticides. Indian J Exp Biol. 2006 Jul;44(7):580-3.

Present work is designed to study the in vitro effects of some organophosphates (ethion, chlorpyrifos, dimethoate and monocrotophos) on rat erythrocytes.
Treatment of erythrocytes with organophosphates resulted in decreased erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) activity, whereas activities of glutathione-s-transferase (GST) and glutathione reductase (GR) were increased.
1(0,0,0,1) Details
15337579 Mahboob M, Kaleem M, Siddiqui J: Effects of a novel organophosphorus pesticide (RPR-V) on extra hepatic detoxifying enzymes after repeated oral doses in rats. Toxicology. 2004 Oct 1;202(3):159-64.


The effects of a novel organophosphorous pesticide, 2-butenoic acid-3-(diethoxy phosphinothionyl) ethyl ester (RPR-V) on glutathione S-transferases (GST), UDP-glucuronyl transferases (UDPGT) and the level of glutathione (GSH) were evaluated in rats after repeated oral administration at 33 microg kg (-1) day (-1) (low), 66 microg kg (-1) day (-1) (mid) and 99 microg kg (-1) day (-1) (high) for 90 days and at 28 days (withdrawal) post-treatment.
1(0,0,0,1) Details
12622178 Khan IA, Reddy BV, Mahboob M, Rahman MF, Jamil K: Acute and sub-acute effects of 2-butenoic acid-3-(diethoxy phosphinothioyl) methyl ester (RPR-II) on testis of albino rat. Indian J Exp Biol. 2002 Feb;40(2):162-8.


Testis glutathione (GSH) level and glutathione S-transferase (GST) activity was significantly decreased whereas, acid phosphatase (AcP) levels increased significantly at 24 hr post-treatment.
1(0,0,0,1) Details
12485578 Mahboob M, Siddiqui MK: Long-term effects of a novel phosphorothionate (RPR-II) on detoxifying enzymes in brain, lung, and kidney rats. Ecotoxicol Environ Saf. 2002 Nov;53(3):355-60.


The effects of a phosphorothionate, 2-butenoic acid-3-(diethoxyphosphinothioyl) methyl ester (RPR-II), on the activities of glutathione S-transferase (GST) and UDP-glucuronyltransferase (UDPGT) and the level of glutathione (GSH) were evaluated in rats after administration of RPR-II at 0.014 (low), 0.028 (medium), and 0.042 (high) mgkg (-1) day (-1) for 90 days and also at 28 days (withdrawal) after stopping treatment.
1(0,0,0,1) Details
16765096 Venkateswara Rao J: Sublethal effects of an organophosphorus insecticide (RPR-II) on biochemical parameters of tilapia, Oreochromis mossambicus. Comp Biochem Physiol C Toxicol Pharmacol. 2006 Aug;143(4):492-8. Epub 2006 May 10.


The induction in hepatic glutathione-S-transferase (GST) levels indicates protection against the toxicity of xenobiotic-induced lipid peroxidation.
1(0,0,0,1) Details