Protein Information

Name catalase
Synonyms CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases…

Compound Information

Name endosulfan
CAS 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide

Reference List

PubMed Abstract RScore(About this table)
20121021 Vidyasagar GM, Kotresha D, Sreenivasa N, Karnam R: Role of endosulfan in mediating stress responses in Sorghum bicolor (L.) Moench. J Environ Biol. 2009 Mar;30(2):217-20.

Endosulfan treatment suppressed the catalase and protease activity, but significantly increased the level of peroxidase, polyphenol oxidase, SOD and amylase enzymes.
81(1,1,1,1) Details
14550752 Dorval J, Hontela A: Role of glutathione redox cycle and catalase in defense against oxidative stress induced by endosulfan in adrenocortical cells of rainbow trout (Oncorhynchus mykiss). Toxicol Appl Pharmacol. 2003 Oct 15;192(2):191-200.

Aminotriazole (ATA), an inhibitor of catalase (CAT), L-buthionine sulfoximine (L-BSO), an inhibitor of glutathione (GSH) synthesis, and N-acetyl cysteine (NAC), a glutathione precursor, were used to investigate the role of CAT and GSH redox cycle in protection against the adrenal toxicity of endosulfan, a pesticide that impairs cell viability (LC50 366 microM) and cortisol secretion (EC50 19 microM) in a concentration-related manner.
43(0,1,3,3) Details
20027135 Slaninova A, Smutna M, Modra H, Svobodova Z: A review: oxidative stress in fish induced by pesticides. Neuro Endocrinol Lett. 2009;30 Suppl 1:2-12.

Activation of spleen macrophages and a decrease of catalase (CAT) activity have been observed after endosulfan exposure.
32(0,1,1,2) Details
18584851 Kumar S, Habib K, Fatma T: Endosulfan induced biochemical changes in nitrogen-fixing cyanobacteria. Sci Total Environ. 2008 Sep 15;403(1-3):130-8. Epub 2008 Jun 26.

Reduction in growth, photosynthetic pigments and carbohydrate of the test microorganisms were accompanied with increase in their total protein, proline, malondialdehye (MDA), superoxide dismutase (SOD), ascorbate peroxidase (APX) and catalase (CAT) in higher endosulfan doses.
31(0,1,1,1) Details
15337585 Kalender S, Kalender Y, Ogutcu A, Uzunhisarcikli M, Durak D, Acikgoz F: Endosulfan-induced cardiotoxicity and free radical metabolism in rats: the protective effect of vitamin E. Toxicology. 2004 Oct 1;202(3):227-35.

The aim of this work was to study antioxidant enzyme system which include superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) and malondialdehyde (MDA), the end product of lipid peroxidation and ultrastructural changes that might occur in the heart tissue of adult male Wistar rats as a result of endosulfan intoxication.
31(0,1,1,1) Details
15907763 Barata C, Varo I, Navarro JC, Arun S, Porte C: Antioxidant enzyme activities and lipid peroxidation in the freshwater cladoceran Daphnia magna exposed to redox cycling compounds. Comp Biochem Physiol C Toxicol Pharmacol. 2005 Feb;140(2):175-86. Epub 2005 Feb 24.

Activities of key antioxidant enzymes including catalase, superoxide dismutase, glutathione peroxidase and glutathione S-transferases and levels of lipid peroxidation measured as thiobarbituric acid-reactive substances (TBARS) and lipofucsin pigment content were determined in D. magna juveniles after being exposed to sublethal levels of menadione, paraquat, endosulfan, cadmium and copper for 48 h.
7(0,0,1,2) Details
19957884 Pal R, Ahmed T, Kumar V, Suke SG, Ray A, Banerjee BD: Protective effects of different antioxidants against endosulfan-induced oxidative stress and immunotoxicity in albino rats. Indian J Exp Biol. 2009 Sep;47(9):723-9.

Endosulfan exposure (8 and 16 mg/kg) to rats significantly decreased the activities of superoxide dismutase and catalase, level of reduced glutathione and increased lipid peroxidation.
6(0,0,1,1) Details
17201197 Syakalima M, Choongo K, Mwenechanya R, Wepener V, Yamasaki M, Maede Y: Pesticide/herbicide pollutants in the Kafue River and a preliminary investigation into their biological effect through catalase levels in fish. Jpn J Vet Res. 2006 Nov;54(2-3):119-28.

The pesticides/herbicides detected in all samples collectively included: Heptachlor, pp'-DDE, Cypermethrin, Chlordane, Toxaphene, Terbufos, Kelthane, Endosulfan, Dieldrin, pp'-DDD, pp'-DDT, Atrazine, Disulfoton, d-trans-Allethrin and Endrin.
6(0,0,0,6) Details
15942872 Prasad SM, Kumar D, Zeeshan M: Growth, photosynthesis, active oxygen species and antioxidants responses of paddy field cyanobacterium Plectonema boryanum to endosulfan stress. J Gen Appl Microbiol. 2005 Apr;51(2):115-23.

As a consequence of active oxygen species (AOS) generation in endosulfan-treated cells, the activity of superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD) was enhanced considerably.
6(0,0,1,1) Details
11503072 Pandey S, Ahmad I, Parvez S, Bin-Hafeez B, Haque R, Raisuddin S: Effect of endosulfan on antioxidants of freshwater fish Channa punctatus Bloch: 1. Arch Environ Contam Toxicol. 2001 Oct;41(3):345-52.

Effect of a single exposure of endosulfan (5 ppb) on catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), and reduced glutathione (GSH) of liver, kidney, and gill of a freshwater fish (Channa punctatus Bloch) were evaluated after 24 h of treatment.
6(0,0,1,1) Details
12716052 Bebe FN, Panemangalore M: Exposure to low doses of endosulfan and chlorpyrifos modifies endogenous antioxidants in tissues of rats. J Environ Sci Health B. 2003 May;38(3):349-63.

Two experiments were conducted in male SD rats (225-250 g) to determine changes in the activities of endogenous antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and concentrations of glutathione (GSH) in tissues after exposure to low doses of endosulfan and chlorpyrifos using a whole body exposure technique.
6(0,0,1,1) Details
17189834 Jia Z, Misra HP: Reactive oxygen species in in vitro pesticide-induced neuronal cell (SH-SY5Y) cytotoxicity: role of NFkappaB and caspase-3. Free Radic Biol Med. 2007 Jan 15;42(2):288-98. Epub 2006 Oct 28.

We have, therefore, examined the role of oxidative stress caused by the pesticides endosulfan and zineb in human neuroblastoma cells (SH-SY5Y) in culture.
Pesticide treatment decreased superoxide dismutase, glutathione peroxidase, and catalase activities in SH-SY5Y cells.
1(0,0,0,1) Details
18443843 Aggarwal M, Naraharisetti SB, Sarkar SN, Rao GS, Degen GH, Malik JK: Effects of subchronic coexposure to arsenic and endosulfan on the erythrocytes of broiler chickens: a biochemical study. Arch Environ Contam Toxicol. 2009 Jan;56(1):139-48. Epub 2008 Apr 29.

At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.
1(0,0,0,1) Details
18179806 Menone ML, Pesce SF, Diaz MP, Moreno VJ, Wunderlin DA: Endosulfan induces oxidative stress and changes on detoxication enzymes in the aquatic macrophyte Myriophyllum quitense. Phytochemistry. 2008 Mar;69(5):1150-7. Epub 2008 Jan 7.

Thus, we measured the activities of catalase (CAT), soluble and membrane associated glutathione-S-transferases (s- and m-GSTs) and glutathione reductase (GR), as well as the hydrogen peroxide (H2O2) content.
1(0,0,0,1) Details
12711413 Dorval J, Leblond VS, Hontela A: Oxidative stress and loss of cortisol secretion in adrenocortical cells of rainbow trout (Oncorhynchus mykiss) exposed in vitro to endosulfan, an organochlorine pesticide. Aquat Toxicol. 2003 May 8;63(3):229-41.

0(0,0,0,0) Details