| Name | mitogen activated protein kinase (protein family or complex) |
|---|---|
| Synonyms | MAPK; mitogen activated protein kinase; mitogen activated protein kinases |
| Name | endosulfan |
|---|---|
| CAS | 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11767051 | Kang KS, Park JE, Ryu DY, Lee YS: Effects and neuro-toxic mechanisms of 2, 2', 4, 4', 5, 5'-hexachlorobiphenyl and endosulfan in neuronal stem cells. J Vet Med Sci. 2001 Nov;63(11):1183-90. In order to know the neuro-toxic mechanisms of 2, 4, 5-HCB and endosulfan in neuronal stem cells, we investigated mitogen-activated protein kinase activity (MAPK) and gap junctional intercellular communication (GJIC). |
12(0,0,2,2) | Details |
| 16413991 | Li X, Zhang S, Safe S: Activation of kinase pathways in MCF-7 cells by 17beta- and structurally diverse estrogenic compounds. J Steroid Biochem Mol Biol. 2006 Feb;98(2-3):122-32. Epub 2006 Jan 18. 17beta- (E2) activates non-genomic pathways in MCF-7 cells, and this study investigates the effects of structurally-diverse estrogenic compounds on activation of mitogen-activated protein kinase (MAPK), phosphatidylinositol-3-kinase (PI3-K), protein kinase C (PKC), PKA, and calmodulin-dependent kinase IV (CaMKIV). The compounds investigated in this study include E2, diethylstilbestrol (DES), the phytoestrogen and the following synthetic xenoestrogens, bisphenol-A (BPA), nonylphenol, octylphenol, endosulfan, kepone, 2,2-bis (p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), and 2',3',4',5'-tetrachloro-4-biphenylol (HO-PCB-Cl (4)). |
2(0,0,0,2) | Details |
| 17503468 | Antherieu S, Ledirac N, Luzy AP, Lenormand P, Caron JC, Rahmani R: Endosulfan decreases cell growth and apoptosis in human HaCaT keratinocytes: partial ROS-dependent ERK1/2 mechanism. J Cell Physiol. 2007 Oct;213(1):177-86. This insecticide was recently reported to alter the mitogen-activated protein (MAP) kinase signaling pathways and is suspected to affect cell growth and differentiation in human keratinocytes. |
1(0,0,0,1) | Details |
| 15888667 | Ledirac N, Antherieu S, d'Uby AD, Caron JC, Rahmani R: Effects of organochlorine insecticides on MAP kinase pathways in human HaCaT keratinocytes: key role of reactive species. Toxicol Sci. 2005 Aug;86(2):444-52. Epub 2005 May 11. The aim of this study was to investigate the effects of four OCs (dieldrin, endosulfan, heptachlor, and lindane) on mitogen-activated protein kinase (MAPK) cascades and more specifically to identify the mechanism underlying OC-induced ERK1/2 activation. |
31(0,1,1,1) | Details |