Protein Information

Name Connexin 43
Synonyms CX43; Connexin 43; Cx43; DFNB38; GJA 1; GJA1; GJAL; Gap junction 43 kDa heart protein…

Compound Information

Name endosulfan
CAS 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide

Reference List

PubMed Abstract RScore(About this table)
11787861 Matesic DF, Blommel ML, Sunman JA, Cutler SJ, Cutler HG: Prevention of organochlorine-induced inhibition of gap junctional communication by chaetoglobosin K in astrocytes. Cell Biol Toxicol. 2001;17(6):395-408.

In this study, the organochlorine xenobiotics dieldrin and endosulfan, at micromolar concentrations, were found to inhibit gap junction-mediated intercellular communication and induce hypophosphorylation of connexin 43 in cultured rat astrocytes, the predominant cell type in the brain coupled through gap junctions.
88(1,1,2,3) Details
8020150 Kenne K, Fransson-Steen R, Honkasalo S, Warngard L: Two inhibitors of gap junctional intercellular communication, TPA and endosulfan: different effects on phosphorylation of connexin 43 in the rat liver epithelial cell line, IAR 20. Carcinogenesis. 1994 Jun;15(6):1161-5.
87(1,1,2,2) Details
11767051 Kang KS, Park JE, Ryu DY, Lee YS: Effects and neuro-toxic mechanisms of 2, 2', 4, 4', 5, 5'-hexachlorobiphenyl and endosulfan in neuronal stem cells. J Vet Med Sci. 2001 Nov;63(11):1183-90.

Endosulfan and 2, 4, 5-HCB inhibited GJIC compared to the untreated cell by scrape loading dye transfer (SL/DT). 2, 4, 5-HCB and endosulfan decreased the expression of connexin 43 in dose dependent manner.
31(0,1,1,1) Details