Protein Information

Name ATPases
Synonyms (NA+ + K+)ATPase; ATP1A1; ATPase; ATPase Na+/K+ transporting alpha 1 polypeptide; Na (+) K (+) ATPase; Na (+),K (+) ATPase; Na + K + ATPase; Na K + ATPase…

Compound Information

Name endosulfan
CAS 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide

Reference List

PubMed Abstract RScore(About this table)
6180524 Wali RK, Singh R, Dudeja PK, Mahmood A: Effect of a single oral dose of endosulfan on intestinal uptake of nutrients and on brush-border enzymes in rats. Toxicol Lett. 1982 Jun;12(1):7-12.

The activities of brush-border sucrase and alkaline phosphatase were considerably increased while the activity of Na+ K+ ATPase was reduced in endosulfan-exposed animals.
81(1,1,1,1) Details
1685416 Reddy DC, Kalarani V, Davies RW: Tissue ATPase activity and recovery in the freshwater crab Oziotelphusa senex senex exposed to a sublethal concentration of endosulfan for varying periods of time. Comp Biochem Physiol C. 1991;99(3):431-5.

Na (+)-K+ and Mg (2+)-tissue ATPases of the freshwater crab Oziotelphusa senex senex showed increasing inhibition when exposed to a sublethal concentration (1.86 mg/l = 0.1 of LC50) of endosulfan for 1-30 days. 2.
31(0,1,1,1) Details
18443843 Aggarwal M, Naraharisetti SB, Sarkar SN, Rao GS, Degen GH, Malik JK: Effects of subchronic coexposure to arsenic and endosulfan on the erythrocytes of broiler chickens: a biochemical study. Arch Environ Contam Toxicol. 2009 Jan;56(1):139-48. Epub 2008 Apr 29.

Na+-K+-ATPase activity was decreased in the endosulfan-treated and the coexposed birds.
7(0,0,1,2) Details
1311216 Reddy AN, Venugopal NB, Reddy SL: Effect of endosulfan 35 EC on ATPases in the tissues of a freshwater field crab Barytelphusa guerini. Bull Environ Contam Toxicol. 1992 Feb;48(2):216-22.
6(0,0,1,1) Details
2851197 Kiran R, Varma MN: Biochemical studies on endosulfan toxicity in different age groups of rats. Toxicol Lett. 1988 Dec;44(3):247-52.

In contrast to these changes, erythrocyte (Na+, K+)-ATPase was maximally inhibited in 15-day-old rats.
1(0,0,0,1) Details
7900959 Naqvi SM, Vaishnavi C: Bioaccumulative potential and toxicity of endosulfan insecticide to non-target animals. Comp Biochem Physiol C. 1993 Jul;105(3):347-61.

It also decreased significantly Na+, K+ and Mg (2+) ATPases, plasma calcium level and alkaline phosphatase in the intestinal epithelium. 6.
1(0,0,0,1) Details